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6jc3

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==The Cryo-EM structure of nucleoprotein-RNA complex of Newcastle disease virus==
==The Cryo-EM structure of nucleoprotein-RNA complex of Newcastle disease virus==
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<StructureSection load='6jc3' size='340' side='right'caption='[[6jc3]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
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<SX load='6jc3' size='340' side='right' viewer='molstar' caption='[[6jc3]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jc3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_orthoavulavirus_1 Avian orthoavulavirus 1] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JC3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jc3 OCA], [http://pdbe.org/6jc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jc3 RCSB], [http://www.ebi.ac.uk/pdbsum/6jc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jc3 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jc3 OCA], [https://pdbe.org/6jc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jc3 RCSB], [https://www.ebi.ac.uk/pdbsum/6jc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jc3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/D6R3F6_9MONO D6R3F6_9MONO]] Encapsidates the genome, protecting it from nucleases.[RuleBase:RU361245]
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[https://www.uniprot.org/uniprot/D6R3F6_9MONO D6R3F6_9MONO] Encapsidates the genome, protecting it from nucleases.[RuleBase:RU361245]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Non-segmented negative-strand RNA viruses, such as measles, ebola and Newcastle disease viruses (NDV), encapsidate viral genomic RNAs into helical nucleocapsids, which serve as the template for viral replication and transcription. Here, the clam-shaped nucleocapsid structure, where the NDV viral genome is sequestered, was determined at 4.8 A resolution by cryo-electron microscopy. The clam-shaped structure is composed of two single-turn spirals packed in a back-to-back mode. This tightly packed structure functions as a seed for the assembly of a nucleocapsid from both directions, facilitating the growth of double-headed filaments with two separate RNA strings inside. Disruption of this structure by mutations in its loop interface yielded a single-headed unfunctional filament.
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Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome.,Song X, Shan H, Zhu Y, Hu S, Xue L, Chen Y, Ding W, Niu T, Gu J, Ouyang S, Shen QT, Liu ZJ Elife. 2019 Jul 10;8. pii: 45057. doi: 10.7554/eLife.45057. PMID:31290740<ref>PMID:31290740</ref>
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6jc3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Avian orthoavulavirus 1]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ding, W]]
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[[Category: Ding W]]
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[[Category: Liu, Z J]]
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[[Category: Liu ZJ]]
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[[Category: Ouyang, S]]
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[[Category: Ouyang S]]
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[[Category: Shan, H]]
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[[Category: Shan H]]
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[[Category: Shen, Q T]]
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[[Category: Shen QT]]
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[[Category: Song, X]]
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[[Category: Song X]]
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[[Category: Zhu, Y]]
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[[Category: Zhu Y]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear protein-rna complex]]
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[[Category: Self-capping helical structure complex]]
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Current revision

The Cryo-EM structure of nucleoprotein-RNA complex of Newcastle disease virus

6jc3, resolution 4.80Å

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