1wbe

From Proteopedia

(Difference between revisions)

Current revision

X-ray structure of bovine GLTP

Structural highlights

1wbe is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.36Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLTP_BOVIN Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties.

Structural evidence for adaptive ligand binding of glycolipid transfer protein.,Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lin X, Mattjus P, Pike HM, Windebank AJ, Brown RE. Cloning and expression of glycolipid transfer protein from bovine and porcine brain. J Biol Chem. 2000 Feb 18;275(7):5104-10. PMID:10671554
↑ Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA. Structural evidence for adaptive ligand binding of glycolipid transfer protein. J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699 doi:10.1016/j.jmb.2005.10.031
↑ Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA. Structural evidence for adaptive ligand binding of glycolipid transfer protein. J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699 doi:10.1016/j.jmb.2005.10.031

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wbe"

@@ Line 3: / Line 3: @@
 <StructureSection load='1wbe' size='340' side='right'caption='[[1wbe]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wbe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WBE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wbe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WBE FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tfj|1tfj]], [[2bv7|2bv7]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbe OCA], [http://pdbe.org/1wbe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wbe RCSB], [http://www.ebi.ac.uk/pdbsum/1wbe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wbe ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbe OCA], [https://pdbe.org/1wbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wbe RCSB], [https://www.ebi.ac.uk/pdbsum/1wbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wbe ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLTP_BOVIN GLTP_BOVIN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:10671554</ref> <ref>PMID:16309699</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Bos taurus]]
 [[Category: Large Structures]]
-[[Category: Airenne, T T]]
+[[Category: Airenne TT]]
-[[Category: Kidron, H]]
+[[Category: Kidron H]]
-[[Category: Mattjus, P]]
+[[Category: Mattjus P]]
-[[Category: Nylund, M]]
+[[Category: Nylund M]]
-[[Category: Nymalm, Y]]
+[[Category: Nymalm Y]]
-[[Category: Salminen, T A]]
+[[Category: Salminen TA]]
-[[Category: West, G]]
+[[Category: West G]]
-[[Category: Acetylation]]
-[[Category: Glycolipid transfer]]
-[[Category: Glycolipid transfer protein]]
-[[Category: Lipid transport]]

1wbe

From Proteopedia

Current revision

X-ray structure of bovine GLTP

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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