6paw

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'''Unreleased structure'''
 
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The entry 6paw is ON HOLD until Paper Publication
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==Crystal structure of DAPK2 S308A Calcium/Calmodulin complex==
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<StructureSection load='6paw' size='340' side='right'caption='[[6paw]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6paw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PAW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.953&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6paw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6paw OCA], [https://pdbe.org/6paw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6paw RCSB], [https://www.ebi.ac.uk/pdbsum/6paw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6paw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DAPK2_HUMAN DAPK2_HUMAN] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.<ref>PMID:10376525</ref> <ref>PMID:10629061</ref> <ref>PMID:21408167</ref> <ref>PMID:11230133</ref> <ref>PMID:11980920</ref> <ref>PMID:17347302</ref> <ref>PMID:18957423</ref> Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.<ref>PMID:10376525</ref> <ref>PMID:10629061</ref> <ref>PMID:21408167</ref> <ref>PMID:11230133</ref> <ref>PMID:11980920</ref> <ref>PMID:17347302</ref> <ref>PMID:18957423</ref>
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Authors: Simon, B., Wilmanns, M.
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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Description: Crystal structure of DAPK2 S308A Calcium/Calmodulin complex
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*[[Death-associated protein kinase 3D structures|Death-associated protein kinase 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Simon, B]]
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<references/>
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[[Category: Wilmanns, M]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Simon B]]
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[[Category: Wilmanns M]]

Current revision

Crystal structure of DAPK2 S308A Calcium/Calmodulin complex

PDB ID 6paw

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