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6pzp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of caspase-1 in complex with VX-765== | |
| + | <StructureSection load='6pzp' size='340' side='right'caption='[[6pzp]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6pzp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PZP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P7S:N-(4-amino-3-chlorobenzene-1-carbonyl)-3-methyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-prolinamide'>P7S</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pzp OCA], [https://pdbe.org/6pzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pzp RCSB], [https://www.ebi.ac.uk/pdbsum/6pzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pzp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Liu | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liu Z]] | ||
| + | [[Category: Xiao TS]] | ||
| + | [[Category: Yang J]] | ||
Current revision
Crystal structure of caspase-1 in complex with VX-765
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Categories: Homo sapiens | Large Structures | Liu Z | Xiao TS | Yang J
