6fcj
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6fcj' size='340' side='right'caption='[[6fcj]], [[Resolution|resolution]] 2.49Å' scene=''> | <StructureSection load='6fcj' size='340' side='right'caption='[[6fcj]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FCJ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D4W:4-[2-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [https://pdbe.org/6fcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [https://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> |
==See Also== | ==See Also== | ||
| Line 17: | Line 17: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Eggenweiler | + | [[Category: Eggenweiler H-M]] |
| - | [[Category: Lehmann | + | [[Category: Lehmann M]] |
| - | [[Category: Musil | + | [[Category: Musil D]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations
| |||||||||||
