1bpo

From Proteopedia

(Difference between revisions)

Current revision

CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER

Structural highlights

1bpo is a 3 chain structure with sequence from Rattus norvegicus. The April 2007 RCSB PDB Molecule of the Month feature on Clathrin by Graham T. Johnson and David S. Goodsell is 10.2210/rcsb_pdb/mom_2007_4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.6Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CLH1_RAT Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Clathrin triskelions form the lattice that organizes recruitment of proteins to coated pits and helps drive vesiculation of the lipid bilayer. We report the crystal structure at 2.6 A resolution of a 55 kDa N-terminal fragment from the 190 kDa clathrin heavy chain. The structure comprises the globular "terminal domain" and the linker that joins it to the end of a triskelion leg. The terminal domain is a seven-blade beta propeller, a structure well adapted to interaction with multiple partners, such as the AP-1 and AP-2 sorting adaptor complexes and the nonvisual arrestins. The linker is an alpha-helical zigzag emanating from the propeller domain. We propose that this simple motif may extend into the rest of the clathrin leg.

Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.,ter Haar E, Musacchio A, Harrison SC, Kirchhausen T Cell. 1998 Nov 13;95(4):563-73. PMID:9827808^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell. 1998 Nov 13;95(4):563-73. PMID:9827808

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bpo"

@@ Line 3: / Line 3: @@
 <StructureSection load='1bpo' size='340' side='right'caption='[[1bpo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1bpo]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. The April 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Clathrin''  by Graham T. Johnson and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 10.2210/rcsb_pdb/mom_2007_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BPO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1bpo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The April 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Clathrin''  by Graham T. Johnson and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 10.2210/rcsb_pdb/mom_2007_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BPO FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpo OCA], [http://pdbe.org/1bpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bpo RCSB], [http://www.ebi.ac.uk/pdbsum/1bpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpo ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bpo OCA], [https://pdbe.org/1bpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bpo RCSB], [https://www.ebi.ac.uk/pdbsum/1bpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bpo ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CLH1_RAT CLH1_RAT]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
+[https://www.uniprot.org/uniprot/CLH1_RAT CLH1_RAT] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Clathrin]]
 [[Category: Large Structures]]
 [[Category: RCSB PDB Molecule of the Month]]
-[[Category: Harr, E T]]
+[[Category: Rattus norvegicus]]
-[[Category: Harrison, S C]]
+[[Category: Harr ET]]
-[[Category: Kirchhausen, T]]
+[[Category: Harrison SC]]
-[[Category: Musacchio, A]]
+[[Category: Kirchhausen T]]
-[[Category: Clathrin endocytosis beta-propeller coated-pit]]
+[[Category: Musacchio A]]
-[[Category: Membrane protein]]

1bpo

From Proteopedia

Current revision

CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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