2vuc

<table><tr><td colspan='2'>[[2vuc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VUC FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YX0:[(3E)-3-(1-HYDROXYETHYLIDENE)-2,3-DIHYDROISOXAZOL-5-YL]METHYL+6-DEOXY-ALPHA-L-GALACTOPYRANOSIDE'>YX0</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ovs|1ovs]], [[1oxc|1oxc]], [[1w8f|1w8f]], [[2jdk|2jdk]], [[1oux|1oux]], [[1gzt|1gzt]], [[2jdh|2jdh]], [[2jdy|2jdy]], [[1ous|1ous]], [[2jdu|2jdu]], [[1ovp|1ovp]], [[2jdp|2jdp]], [[1our|1our]], [[1uzv|1uzv]], [[2boj|2boj]], [[2bp6|2bp6]], [[2jdm|2jdm]], [[2jdn|2jdn]], [[1w43|1w43]], [[1w8h|1w8h]], [[2vud|2vud]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vuc OCA], [http://pdbe.org/2vuc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vuc RCSB], [http://www.ebi.ac.uk/pdbsum/2vuc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vuc ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.

Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.,Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289<ref>PMID:12415289</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2vuc" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Beha, S]]

[[Category: Imberty, A]]

[[Category: Marotte, K]]

[[Category: Mitchell, E P]]

[[Category: Roy, R]]

[[Category: Sabin, C]]

[[Category: Sugar-binding protein]]