6u0k
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6u0k is ON HOLD Authors: Marcotte, D.J. Description: TTBK2 kinase domain in complex with Compound 1 Category: Unreleased Structures [[Category:...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==TTBK2 kinase domain in complex with Compound 1== | |
| - | + | <StructureSection load='6u0k' size='340' side='right'caption='[[6u0k]], [[Resolution|resolution]] 1.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u0k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U0K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.744Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTQ:4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE'>DTQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | [[Category: Marcotte | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u0k OCA], [https://pdbe.org/6u0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u0k RCSB], [https://www.ebi.ac.uk/pdbsum/6u0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u0k ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TTBK2_HUMAN TTBK2_HUMAN] Spinocerebellar ataxia type 11. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTBK2_HUMAN TTBK2_HUMAN] Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.<ref>PMID:21548880</ref> <ref>PMID:23141541</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chodaparambil JV]] | ||
| + | [[Category: Marcotte DJ]] | ||
Current revision
TTBK2 kinase domain in complex with Compound 1
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