6u1o
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6u1o is ON HOLD Authors: Harjes, E., Jameson, G.B., Edwards, P.J.B., Goroncy, A.K., Loo, T., Norris, G.E. Description: Structure of two-domain tran...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action== | |
| - | + | <StructureSection load='6u1o' size='340' side='right'caption='[[6u1o]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1o OCA], [https://pdbe.org/6u1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1o RCSB], [https://www.ebi.ac.uk/pdbsum/6u1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1o ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/YIH1_YEAST YIH1_YEAST] Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis (PubMed:15126500, PubMed:15937339, PubMed:24333428). In normal conditions, it resides in a actin complex and has no activity (PubMed:15126500).<ref>PMID:15126500</ref> <ref>PMID:15937339</ref> <ref>PMID:24333428</ref> |
| - | [[Category: Harjes | + | == References == |
| - | [[Category: Loo | + | <references/> |
| - | [[Category: Norris | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Edwards PJB]] | ||
| + | [[Category: Goroncy AK]] | ||
| + | [[Category: Harjes E]] | ||
| + | [[Category: Jameson GB]] | ||
| + | [[Category: Loo T]] | ||
| + | [[Category: Norris GE]] | ||
Current revision
Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action
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