1gmy

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<StructureSection load='1gmy' size='340' side='right'caption='[[1gmy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1gmy' size='340' side='right'caption='[[1gmy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gmy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GMY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gmy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GMY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEM:2-AMINOETHANIMIDIC+ACID'>AEM</scene>, <scene name='pdbligand=APD:3-METHYLPHENYLALANINE'>APD</scene>, <scene name='pdbligand=DFA:DIPHENYLACETIC+ACID'>DFA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1csb|1csb]], [[1huc|1huc]], [[1pbh|1pbh]], [[2pbh|2pbh]], [[3pbh|3pbh]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEM:2-AMINOETHANIMIDIC+ACID'>AEM</scene>, <scene name='pdbligand=APD:3-METHYLPHENYLALANINE'>APD</scene>, <scene name='pdbligand=DFA:DIPHENYLACETIC+ACID'>DFA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gmy OCA], [https://pdbe.org/1gmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gmy RCSB], [https://www.ebi.ac.uk/pdbsum/1gmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gmy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gmy OCA], [http://pdbe.org/1gmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gmy RCSB], [http://www.ebi.ac.uk/pdbsum/1gmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gmy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gmy_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gmy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin B]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bohacek, R S]]
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[[Category: Bohacek RS]]
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[[Category: Capparelli, M P]]
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[[Category: Capparelli MP]]
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[[Category: Clark, K L]]
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[[Category: Clark KL]]
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[[Category: Coppa, D E]]
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[[Category: Coppa DE]]
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[[Category: Cowen, S D]]
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[[Category: Cowen SD]]
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[[Category: Doughty, J R]]
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[[Category: Doughty JR]]
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[[Category: Du, Z]]
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[[Category: Du Z]]
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[[Category: Duzer, J H.van]]
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[[Category: Fang Z]]
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[[Category: Fang, Z]]
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[[Category: Farley DL]]
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[[Category: Farley, D L]]
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[[Category: Fitt JJ]]
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[[Category: Fitt, J J]]
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[[Category: Goldberg RL]]
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[[Category: Goldberg, R L]]
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[[Category: Goldstein R]]
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[[Category: Goldstein, R]]
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[[Category: Greenspan PD]]
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[[Category: Greenspan, P D]]
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[[Category: Knap AK]]
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[[Category: Knap, A K]]
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[[Category: Macchia W]]
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[[Category: Macchia, W]]
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[[Category: McQuire LW]]
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[[Category: McQuire, L W]]
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[[Category: Tommasi RA]]
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[[Category: Tommasi, R A]]
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[[Category: Wigg AM]]
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[[Category: Wigg, A M]]
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[[Category: Zhou H]]
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[[Category: Zhou, H]]
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[[Category: Zhu L]]
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[[Category: Zhu, L]]
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[[Category: Van Duzer JH]]
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[[Category: Cathepsin b]]
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[[Category: Covalent complex]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-inhibitor complex]]
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[[Category: Hydrolase/inhibitor]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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Current revision

Cathepsin B complexed with dipeptidyl nitrile inhibitor

PDB ID 1gmy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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