2mvt

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==Solution structure of scoloptoxin SSD609 from Scolopendra mutilans==
==Solution structure of scoloptoxin SSD609 from Scolopendra mutilans==
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<StructureSection load='2mvt' size='340' side='right'caption='[[2mvt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mvt' size='340' side='right'caption='[[2mvt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mvt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_red-headed_centipede Chinese red-headed centipede]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MVT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scolopendra_subspinipes Scolopendra subspinipes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MVT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvt OCA], [http://pdbe.org/2mvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mvt RCSB], [http://www.ebi.ac.uk/pdbsum/2mvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvt ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mvt OCA], [https://pdbe.org/2mvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mvt RCSB], [https://www.ebi.ac.uk/pdbsum/2mvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mvt ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TX31A_SCODE TX31A_SCODE] Toxin that acts on KCNE1 and to a lesser extent KCNE3, the auxiliary subunits of potassium channel Kv7.1/KNCQ1 (PubMed:26307551). The toxin reversibly inhibits the slow delayed rectifier potassium currents (IKs) exhibited by the complex KCNQ1-KCNE1 (IC(50)=652 nM) and by the complex KCNQ1-KCNE3 (30% inhibition at 1 uM) (PubMed:26307551). The positively charged part of toxin binds to the negatively charged residues of the N-terminal amphipathic helix from the KCNE1 extracellular region (PubMed:26307551).<ref>PMID:26307551</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chinese red-headed centipede]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: He, Y]]
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[[Category: Scolopendra subspinipes]]
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[[Category: Sun, P]]
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[[Category: He Y]]
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[[Category: Tian, C]]
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[[Category: Sun P]]
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[[Category: Wang, C]]
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[[Category: Tian C]]
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[[Category: Wu, F]]
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[[Category: Wang C]]
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[[Category: Zhang, L]]
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[[Category: Wu F]]
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[[Category: Toxin]]
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[[Category: Zhang L]]

Current revision

Solution structure of scoloptoxin SSD609 from Scolopendra mutilans

PDB ID 2mvt

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