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Importin 3D structures

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(New page: ==3D structures of importin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IPO-α **1ial – mIPO NLS-bind...)
Current revision (07:10, 29 May 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 7: Line 7:
**[[1ial]] – mIPO NLS-binding domain – mouse<br />
**[[1ial]] – mIPO NLS-binding domain – mouse<br />
-
**[[1bk5]] – yIPO NLS-binding domain - yeast<br />
+
**[[6d7m]] – mIPO (mutant)<br />
**[[4tnm]] – IPO armadillo repeat domain – ''Arabidopsis thaliana''<br />
**[[4tnm]] – IPO armadillo repeat domain – ''Arabidopsis thaliana''<br />
 +
**[[1bk5]] – yIPO NLS-binding domain - yeast<br />
 +
**[[7vps]] – NgIPO ARM domain 75-516 – ''Nakaceomyces glabratus''<br />
*''IPO-α complex with NLS peptide''
*''IPO-α complex with NLS peptide''
Line 25: Line 27:
**[[4rxh]] – NcIPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa''<br />
**[[4rxh]] – NcIPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa''<br />
**[[5vqi]] – NcIPO NLS-binding domain + NIT2<br />
**[[5vqi]] – NcIPO NLS-binding domain + NIT2<br />
 +
**[[7vpt]] – NgIPO ARM domain + Upc2<br />
*''IPO-α complex with protein''
*''IPO-α complex with protein''
Line 34: Line 37:
*IPO-α 1
*IPO-α 1
-
**[[3wpt]] – hIPO NLS-binding domain - human<br />
+
**[[3wpt]], [[8fzk]] – hIPO NLS-binding domain - human<br />
**[[4b8j]] – rIPO <br />
**[[4b8j]] – rIPO <br />
**[[6bvt]] – mIPO NLS-binding domain <br />
**[[6bvt]] – mIPO NLS-binding domain <br />
 +
**[[4u5v]], [[4u5u]], [[4u5s]], [[4u5o]], [[4u5n]], [[4u5l]], [[4u58]], [[4u54]] – mIPO NLS-binding domain + inhibitor<br />
 +
**[[8g4j]] – IPO – guinea pig<br />
*''IPO-α 1 complex with NLS peptide''
*''IPO-α 1 complex with NLS peptide''
Line 45: Line 50:
**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
 +
**[[7n9h]] – hIPO NLS-binding domain + TDP-43 peptide<br />
 +
**[[7cru]] – hIPO NLS-binding domain + hnRNPK peptide<br />
 +
**[[8he3]] – hIPO NLS-binding domain + HIF-1 peptide<br />
 +
**[[7n8j]] – hIPO NLS-binding domain + BIMAX peptide<br />
**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
-
**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase<br />
+
**[[8gai]] – IPO NLS-binding domain + BIMAX peptide – guinea pig<br />
 +
**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain 70-528 + dUTPase<br />
**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
**[[5svz]] – mIPO NLS-binding domain + TAT NLS motif<br />
**[[5svz]] – mIPO NLS-binding domain + TAT NLS motif<br />
Line 55: Line 65:
**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2<br />
**[[5ekg]], [[5ekf]], [[5e6q]] – mIPO NLS-binding domain + XPG2<br />
**[[5d5k]] – mIPO NLS-binding domain + PARP 2<br />
**[[5d5k]] – mIPO NLS-binding domain + PARP 2<br />
 +
**[[7l04]], [[8fk3]] – mIPO NLS-binding domain + adeno-associated virus<br />
**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110<br />
**[[5ctt]] – mIPO NLS-binding domain + SART3/TIP110<br />
**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR<br />
**[[5b56]] – mIPO NLS-binding domain + HIV-1 VPR<br />
Line 63: Line 74:
**[[6iu7]], [[6iua]] – mIPO NLS-binding domain + TP53-binding protein <br />
**[[6iu7]], [[6iua]] – mIPO NLS-binding domain + TP53-binding protein <br />
**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />
**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />
 +
**[[8fua]], [[8fuc]] – mIPO NLS-binding domain + Hendra virus peptide<br />
 +
**[[8ech]] – mIPO NLS-binding domain + tick-bourne encephalitis virus<br />
**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />
**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />
-
**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />
+
**[[5u5p]], [[5u5r]], [[6wba]], [[6wbb]], [[6wbc]], [[7m60]] – mIPO NLS-binding domain + MLH1 peptide <br />
**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
 +
**[[6iw8]], [[6iwa]] – mIPO NLS-binding domain + GM130 peptide <br />
 +
**[[6k06]] – mIPO NLS-binding domain (mutant) + GM130 peptide <br />
 +
**[[6mjl]] – mIPO NLS-binding domain + CHREBP peptide <br />
 +
**[[6p6a]] – mIPO NLS-binding domain + NIT-2 peptide <br />
 +
**[[6p6e]] – mIPO NLS-binding domain + PAC3 peptide <br />
 +
**[[7jjm]], [[7jk7]] – mIPO NLS-binding domain + LSD1 peptide <br />
 +
**[[7jvo]] – mIPO NLS-binding domain + ACE2 peptide <br />
 +
**[[8he0]] – mIPO NLS-binding domain + HIF-1 peptide<br />
 +
**[[7rg4]], [[7rg5]] – mIPO NLS-binding domain + p50 peptide <br />
 +
**[[6wx7]] – mIPO NLS-binding domain + SOX2 peptide <br />
**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
**[[4b8p]] – rIPO NLS-binding domain + A89<br />
**[[4b8p]] – rIPO NLS-binding domain + A89<br />
Line 92: Line 115:
**[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase <br />
**[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase <br />
**[[2c1m]] – mIPO NLS-binding domain + Nup50<br />
**[[2c1m]] – mIPO NLS-binding domain + Nup50<br />
 +
**[[7leq]] – mIPO NLS-binding domain + p50<br />
 +
**[[7leu]] – mIPO NLS-binding domain + p65<br />
**[[3btr]] – mIPO NLS-binding domain + androgen receptor<br />
**[[3btr]] – mIPO NLS-binding domain + androgen receptor<br />
**[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2<br />
**[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2<br />
Line 100: Line 125:
**[[3tpm]] – mIPO NLS-binding domain + MAL<br />
**[[3tpm]] – mIPO NLS-binding domain + MAL<br />
**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />
**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />
 +
**[[8f2q]] – mIPO NLS-binding domain + parvovirus<br />
**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />
**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />
**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />
**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />
Line 108: Line 134:
**[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS <br />
**[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS <br />
**[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase<br />
**[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase<br />
 +
**[[7jjm]] – mIPO + LSD1 peptide <br />
*''IPO-α 2 complex with protein''
*''IPO-α 2 complex with protein''
**[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
**[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
 +
**[[7rfx]], [[7rfz]], [[7rg0]], [[7rg1]], [[7rg2]], [[7rg3]], [[7rg6]] – mIPO + ORF4b<br />
*IPO-α 3
*IPO-α 3
Line 120: Line 148:
**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />
**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />
**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />
**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />
 +
**[[8hkw]] – hIPO NLS-binding domain + 53BP1 peptide<br />
**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />
**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />
 +
**[[7rfy]] – hIPO + ORF4b<br />
 +
**[[6wx8]] – hIPO + SOX2<br />
 +
**[[7lfc]] – hIPO + p50 NLS<br />
 +
**[[7lf4]] – hIPO + p50 NLS + p65 NLS<br />
 +
**[[8fub]] – hIPO NLS-binding domain + Hendra virus peptide<br />
 +
**[[8fzm]] – mIPO NLS-binding domain + BIMAX<br />
 +
**[[7let]] – mIPO + p50 NLS + p65 NLS<br />
 +
 +
*IPO-α 5
 +
 +
**[[6wx9]] – hIPO + SOX2<br />
*IPO-α 6
*IPO-α 6
Line 128: Line 168:
*IPO-α 7
*IPO-α 7
 +
**[[7rht]] – hIPO <br />
**[[4uad]] – hIPO NLS-binding domain + influenza RNA polymerase<br />
**[[4uad]] – hIPO NLS-binding domain + influenza RNA polymerase<br />
*IPO-β
*IPO-β
-
**[[4xrk]] – IPO – ''Chaetomium thermophilum'' <br />
+
**[[4xri]], [[4xrk]] – IPO – ''Chaetomium thermophilum'' <br />
*IPO-β 1 (karyopherin β 1)
*IPO-β 1 (karyopherin β 1)
Line 143: Line 184:
**[[1qgx]], [[1qgk]] – hIPO + IPO-α 2 IBB domain<br />
**[[1qgx]], [[1qgk]] – hIPO + IPO-α 2 IBB domain<br />
**[[1ibr]] – hIPO + GTPase Ran<br />
**[[1ibr]] – hIPO + GTPase Ran<br />
-
**[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
+
**[[6n88]], [[6n89]] – hIPO + H1.0 – Cryo EM<br />
**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />
**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />
**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />
**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />
**[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal<br />
**[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal<br />
**[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1<br />
**[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1<br />
-
**[[5owu]] – yIPO + Nup1<br />
 
**[[1ukl]] – mIPO + SREBP-2<br />
**[[1ukl]] – mIPO + SREBP-2<br />
 +
**[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
 +
**[[5owu]] – yIPO + Nup1<br />
*IPO-β 2 (Transportin 1)
*IPO-β 2 (Transportin 1)
Line 177: Line 219:
**[[5h2v]] – yIPO + ubiquitin-like specific protease<br />
**[[5h2v]] – yIPO + ubiquitin-like specific protease<br />
**[[4zj7]] – yIPO + CDC14<br />
**[[4zj7]] – yIPO + CDC14<br />
 +
 +
*IPO-β 5 (Karyopherin β 5)
 +
 +
**[[6aho]] – yIPO <br />
 +
 +
*IPO-3
 +
 +
**[[7jjl]] – hIPO + LSD1 peptide <br />
 +
 +
*IPO-4
 +
 +
**[[8dyo]] – hIPO + RanGTP – Cryo EM<br />
 +
**[[7unk]] – hIPO + H3 + H4 + ASF1 – Cryo EM<br />
*IPO-4B
*IPO-4B
Line 182: Line 237:
**[[5xah]] – hIPO residues 668-1081 <br />
**[[5xah]] – hIPO residues 668-1081 <br />
**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />
**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />
 +
 +
*IPO-5
 +
 +
**[[6xte]], [[6xu2]] – hIPO + antipain peptide <br />
*IPO-7
*IPO-7
Line 196: Line 255:
**[[4c0o]] – hIPO + serine/arginine-rich splicing factor<br />
**[[4c0o]] – hIPO + serine/arginine-rich splicing factor<br />
**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran<br />
**[[4c0q]], [[4ol0]] – hIPO + GTPase Ran<br />
 +
**[[6gx9]] – hIPO + CPSF 68<br />
*IPO-13 (karyopherin 13)
*IPO-13 (karyopherin 13)

Current revision

3D structures of importin

Updated on 29-May-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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