6iju

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'''Unreleased structure'''
 
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The entry 6iju is ON HOLD until Paper Publication
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==The DNA binding domain of a response regulator ArlR from Staphylococcus aureus==
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<StructureSection load='6iju' size='340' side='right'caption='[[6iju]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6iju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IJU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iju OCA], [https://pdbe.org/6iju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iju RCSB], [https://www.ebi.ac.uk/pdbsum/6iju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iju ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARLR_STAA8 ARLR_STAA8] Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the presence of the poly-N-acetylglucosamine (PNAG). Also, Arl proteins are required for the efficient activity of DNA gyrase inhibitors and high osmolarity on spa expression.<ref>PMID:10633099</ref> <ref>PMID:10869073</ref> <ref>PMID:11454217</ref> <ref>PMID:15528666</ref> <ref>PMID:16030226</ref>
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Authors: Hui, Y., Qing, W.
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==See Also==
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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Description: The DNA binding domain of a response regulator ArlR from Staphylococcus aureus
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Hui, Y]]
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__TOC__
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[[Category: Qing, W]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus]]
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[[Category: Hui Y]]
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[[Category: Qing W]]

Current revision

The DNA binding domain of a response regulator ArlR from Staphylococcus aureus

PDB ID 6iju

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