6pkw
From Proteopedia
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==Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)== | ==Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)== | ||
| - | < | + | <SX load='6pkw' size='340' side='right' viewer='molstar' caption='[[6pkw]], [[Resolution|resolution]] 4.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6pkw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PKW OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6pkw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PKW FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pkw OCA], [https://pdbe.org/6pkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pkw RCSB], [https://www.ebi.ac.uk/pdbsum/6pkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pkw ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPM2_DANRE TRPM2_DANRE] Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening.<ref>PMID:30250252</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| + | [[Category: Danio rerio]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Borgnia | + | [[Category: Borgnia MJ]] |
| - | [[Category: Borschel | + | [[Category: Borschel WF]] |
| - | [[Category: Hsu | + | [[Category: Hsu AL]] |
| - | [[Category: Lander | + | [[Category: Lander GC]] |
| - | [[Category: Lee | + | [[Category: Lee S-Y]] |
| - | [[Category: Wu | + | [[Category: Wu M]] |
| - | [[Category: Yin | + | [[Category: Yin Y]] |
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Current revision
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)
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Categories: Danio rerio | Large Structures | Borgnia MJ | Borschel WF | Hsu AL | Lander GC | Lee S-Y | Wu M | Yin Y
