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4cn8

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Structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus

Structural highlights

4cn8 is a 1 chain structure with sequence from Mytilus galloprovincialis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.45Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8T5C2_MYTGA

Publication Abstract from PubMed

Blue mussels adhere to surfaces by the byssus, a holdfast structure composed of individual threads representing a collagen fibre reinforced composite. Here, we present the crystal structure and function of one of its matrix proteins, the proximal thread matrix protein 1, which is present in the proximal section of the byssus. The structure reveals two von Willebrand factor type A domains linked by a two-beta-stranded linker yielding a novel structural arrangement. In vitro, the protein binds heterologous collagens with high affinity and affects collagen assembly, morphology and arrangement of its fibrils. By providing charged surface clusters as well as insufficiently coordinated metal ions, the proximal thread matrix protein 1 might interconnect other byssal proteins and thereby contribute to the integrity of the byssal threads in vivo. Moreover, the protein could be used for adjusting the mechanical properties of collagen materials, a function likely important in the natural byssus.

Structural and functional features of a collagen-binding matrix protein from the mussel byssus.,Suhre MH, Gertz M, Steegborn C, Scheibel T Nat Commun. 2014 Feb 26;5:3392. doi: 10.1038/ncomms4392. PMID:24569701^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Suhre MH, Gertz M, Steegborn C, Scheibel T. Structural and functional features of a collagen-binding matrix protein from the mussel byssus. Nat Commun. 2014 Feb 26;5:3392. doi: 10.1038/ncomms4392. PMID:24569701 doi:http://dx.doi.org/10.1038/ncomms4392

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cn8"

@@ Line 3: / Line 3: @@
 <StructureSection load='4cn8' size='340' side='right'caption='[[4cn8]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4cn8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mytga Mytga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CN8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4cn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mytilus_galloprovincialis Mytilus galloprovincialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CN8 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cn9|4cn9]], [[4cnb|4cnb]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cn8 OCA], [https://pdbe.org/4cn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cn8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cn8 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cn8 OCA], [http://pdbe.org/4cn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cn8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cn8 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8T5C2_MYTGA Q8T5C2_MYTGA]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 24: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Mytga]]
+[[Category: Mytilus galloprovincialis]]
-[[Category: Gertz, M]]
+[[Category: Gertz M]]
-[[Category: Scheibel, T]]
+[[Category: Scheibel T]]
-[[Category: Steegborn, C]]
+[[Category: Steegborn C]]
-[[Category: Suhre, M H]]
+[[Category: Suhre MH]]
-[[Category: Structural protein]]

4cn8

From Proteopedia

Current revision

Structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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