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| | <StructureSection load='3vxt' size='340' side='right'caption='[[3vxt]], [[Resolution|resolution]] 2.50Å' scene=''> | | <StructureSection load='3vxt' size='340' side='right'caption='[[3vxt]], [[Resolution|resolution]] 2.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3vxt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VXT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3vxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VXT FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vxm|3vxm]], [[3vxn|3vxn]], [[3vxo|3vxo]], [[3vxp|3vxp]], [[3vxq|3vxq]], [[3vxr|3vxr]], [[3vxs|3vxs]], [[3vxu|3vxu]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxt OCA], [http://pdbe.org/3vxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vxt RCSB], [http://www.ebi.ac.uk/pdbsum/3vxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxt ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxt OCA], [https://pdbe.org/3vxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vxt RCSB], [https://www.ebi.ac.uk/pdbsum/3vxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxt ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Fukai, S]] | + | [[Category: Fukai S]] |
| - | [[Category: Iwamoto, A]] | + | [[Category: Iwamoto A]] |
| - | [[Category: Shimizu, A]] | + | [[Category: Shimizu A]] |
| - | [[Category: Yamagata, A]] | + | [[Category: Yamagata A]] |
| - | [[Category: Hiv-1]]
| + | |
| - | [[Category: Immune response]]
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| - | [[Category: Immune system]]
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| - | [[Category: Immunogloburin domain]]
| + | |
| - | [[Category: Nef]]
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| - | [[Category: T cell receptor]]
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| - | [[Category: Tcr]]
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| Structural highlights
Publication Abstract from PubMed
We investigated the crystal structure of an HLA-A*2402-restricted CTL epitope in the HIV-1 nef gene (Nef134-10) before (pHLA) or after TCR docking. The wild type epitope and two escape mutants were included in the study. Y135F was an early-appearing major mutation, while F139L was a late-appearing mutation which was selected in the patients without Y135F. F139 was an eminent feature of the Nef134-10 epitope. Wild type-specific TCR was less fit to F139L mutant suggesting that F139L is an escape from the CTL against the wild type epitope. Although Y135F mutation disrupted the hydrogen bond to HLA-A*2402 His70, newly formed hydrogen bond between T138 and His70 kept the conformation of the epitope in the reconstituted pMHC. TCR from Y135F- or dually-specific CTL had unique mode of binding to the mutant epitope. Y135F has been reported as a processing mutant but CTL carrying structurally adequate TCR can be found in the patients.
Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.,Shimizu A, Kawana-Tachikawa A, Yamagata A, Han C, Zhu D, Sato Y, Nakamura H, Koibuchi T, Carlson J, Martin E, Brumme CJ, Shi Y, Gao GF, Brumme ZL, Fukai S, Iwamoto A Sci Rep. 2013 Nov 6;3:3097. doi: 10.1038/srep03097. PMID:24192765[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Shimizu A, Kawana-Tachikawa A, Yamagata A, Han C, Zhu D, Sato Y, Nakamura H, Koibuchi T, Carlson J, Martin E, Brumme CJ, Shi Y, Gao GF, Brumme ZL, Fukai S, Iwamoto A. Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection. Sci Rep. 2013 Nov 6;3:3097. doi: 10.1038/srep03097. PMID:24192765 doi:http://dx.doi.org/10.1038/srep03097
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