1b98
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 3: | Line 3: | ||
<StructureSection load='1b98' size='340' side='right'caption='[[1b98]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='1b98' size='340' side='right'caption='[[1b98]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1b98]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1b98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Neurotrophins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_8 10.2210/rcsb_pdb/mom_2005_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B98 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b98 OCA], [https://pdbe.org/1b98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b98 RCSB], [https://www.ebi.ac.uk/pdbsum/1b98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b98 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:[https://omim.org/entry/613100 613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN] Target-derived survival factor for peripheral sensory sympathetic neurons. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 16: | Line 17: | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b98_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b98_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| Line 33: | Line 34: | ||
==See Also== | ==See Also== | ||
*[[Neurotrophin|Neurotrophin]] | *[[Neurotrophin|Neurotrophin]] | ||
| + | *[[Neutrotrophin|Neutrotrophin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Neurotrophins]] | [[Category: Neurotrophins]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Choe | + | [[Category: Choe S]] |
| - | [[Category: Jones | + | [[Category: Jones EY]] |
| - | [[Category: Radziejewski | + | [[Category: Radziejewski C]] |
| - | [[Category: Robinson | + | [[Category: Robinson RC]] |
| - | [[Category: Stuart | + | [[Category: Stuart DI]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
NEUROTROPHIN 4 (HOMODIMER)
| |||||||||||
