4e7y

<table><tr><td colspan='2'>[[4e7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E7Y FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=RKP:LAMBDA-RU(PHEN)2(DPPZ)+COMPLEX'>RKP</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dx4|4dx4]], [[4e87|4e87]], [[4e8s|4e8s]], [[4e8x|4e8x]], [[4e95|4e95]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e7y OCA], [http://pdbe.org/4e7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e7y RCSB], [http://www.ebi.ac.uk/pdbsum/4e7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e7y ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The ruthenium complex [Ru(phen)(2)(dppz)](2+) (where phen is phenanthroline and dppz dipyridophenazine is known as a 'light switch' complex because its luminescence in solution is significantly enhanced in the presence of DNA. This property is poised to serve in diagnostic and therapeutic applications, but its binding mode with DNA needs to be elucidated further. Here, we describe the crystal structures of the Lambda enantiomer bound to two oligonucleotide duplexes. The dppz ligand intercalates symmetrically and perpendicularly from the minor groove of the d(CCGGTACCGG)(2) duplex at the central TA/TA step, but not at the central AT/AT step of d(CCGGATCCGG)(2). In both structures, however, a second ruthenium complex links the duplexes through the combination of a shallower angled intercalation into the C(1)C(2)/G(9)G(10) step at the end of the duplex, and semi-intercalation into the G(3)G(4) step of an adjacent duplex. The TA/TA specificity of the perpendicular intercalation arises from the packing of phenanthroline ligands against the adenosine residue.

Crystal structures of Lambda-[Ru(phen)(2)dppz](2)(+) with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes.,Niyazi H, Hall JP, O'Sullivan K, Winter G, Sorensen T, Kelly JM, Cardin CJ Nat Chem. 2012 Jun 24;4(8):621-8. doi: 10.1038/nchem.1397. PMID:22824893<ref>PMID:22824893</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 4e7y" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Cardin, C J]]

[[Category: Hall, J P]]

[[Category: Intercalation]]