Integrin 3D structures

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(New page: ==3D structures of integrin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IG CR3 **1ido – hIG I domain ...)
Current revision (08:32, 31 May 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 8: Line 8:
**[[1ido]] – hIG I domain + Mg – human<br />
**[[1ido]] – hIG I domain + Mg – human<br />
**[[1jlm]] - hIG I domain + Mn<br />
**[[1jlm]] - hIG I domain + Mn<br />
- 
-
*IG CD11a or IG α-L
 
- 
-
**[[1lfa]] - hIG I domain + Mn<br />
 
-
**[[1zon]] - hIG I domain<br />
 
-
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br />
 
-
**[[1mq9]] - hIG I domain (mutant) + Mn<br />
 
-
**[[1mjn]] - hIG I domain (mutant) + Mg<br />
 
-
**[[1mqa]] - hIG I domain (mutant) <br />
 
-
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR />
 
- 
-
*''IG CD11a complexes''
 
- 
-
**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
 
-
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
 
-
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
 
-
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
 
-
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
 
-
**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
 
-
**[[4ixd]] - hIG I domain + activator + Mg<br />
 
-
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
 
-
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
 
-
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
- 
-
*IG CD11b
 
- 
-
**[[1bho]] - hIG I domain + Mg<br />
 
-
**[[1bhq]] - hIG I domain + Cd<br />
 
-
**[[1m1u]] - hIG I domain (mutant) + Ca<br />
 
-
**[[1n9z]] - hIG I domain (mutant) + Mg<br />
 
-
**[[1idn]], [[1na5]] - hIG I domain<br />
 
-
**[[1mf7]] - hIG I domain (mutant)
 
- 
-
*IG CD11c
 
- 
-
**[[1n3y]] - hIG I domain (mutant)
 
*IG α-1 (CD49a)
*IG α-1 (CD49a)
-
**[[1ck4]] - rIG I domain – rat<br />
 
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[5hgj]] - hIG VWFA domain<br />
**[[5hgj]] - hIG VWFA domain<br />
 +
**[[2m32]] - hIG I domain + collagen peptide<br />
 +
**[[1ck4]] - rIG I domain – rat<br />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
-
**[[2m32]] - hIG I domain + collagen peptide<br />
 
*IG α-2 (CD49b)
*IG α-2 (CD49b)
Line 66: Line 30:
**[[2k1a]] - hIG transmembrane domain – NMR<BR />
**[[2k1a]] - hIG transmembrane domain – NMR<BR />
-
*IG α-1 β-1 (CD49a-CD49b)
+
*IG α-1 + IG β-1 (CD49a-CD49b)
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />
-
*IG α-2 (CD49b) β
+
*IG α-2 (CD49b) + IG β
**[[5hj2]] - hIG I domain<br />
**[[5hj2]] - hIG I domain<br />
Line 77: Line 41:
**[[2k1a]] - hIG transmembrane domain – NMR<br />
**[[2k1a]] - hIG transmembrane domain – NMR<br />
-
*IG α-2b β-3 (CD61)
+
*IG α-2b + IG β-3 (CD61)
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[4cak]] – hIG – Cryo-EM<br />
**[[4cak]] – hIG – Cryo-EM<br />
-
**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
+
**[[2k9j]], [[2knc]], [[7kn0]] - hIG transmembrane domain – NMR<BR />
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg<br />
Line 89: Line 53:
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
 +
**[[6v4p]], [[7la4]] – hIG + antibody – Cryo-EM<br />
 +
**[[7l8p]], [[7tct]], [[7td8]], [[7tho]], [[7tmz]], [[7tpd]], [[7u60]], [[7u9f]], [[7u9v]], [[7ubr]], [[7ucy]], [[7udg]], [[7udh]], [[7ue0]], [[7ufh]], [[7uh8]], [[7uje]], [[7ujk]], [[7uk9]], [[7uko]], [[7ukp]], [[7ukt]] – hIG + antibody + drug<br />
*IG α-4
*IG α-4
Line 94: Line 60:
**[[4irz]] - hIG + antibody <br />
**[[4irz]] - hIG + antibody <br />
-
*IG α-4 (CD49d) β-7
+
*IG α-4 (CD49d) + IG β-7
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
-
*IG α-5 (CD49e) β-1 (CD29)
+
*IG α-5 (CD49e) + IG β-1 (CD29)
 +
**[[7nxd]] – hIG + Mg – Cryo-EM<br />
 +
**[[7nwl]] – hIG + fibronectin + laminin – Cryo-EM<br />
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
Line 106: Line 74:
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
-
*IG α-5 (CD49e) β-3 (CD61) ectodomain
+
*IG α-5 (CD49e) + IG β-3 (CD61) ectodomain
**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
Line 114: Line 82:
**[[1l5g]] - hIG + tripeptide + Mn<br />
**[[1l5g]] - hIG + tripeptide + Mn<br />
-
*IG α-5 β-6
+
*IG α-5 + IG β-6
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
Line 121: Line 89:
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
 +
 +
*IG α-6 + IG β-1
 +
**[[7ceb]], [[7cec]] – hIG headpiece + laminin + Mg<br />
*IG α-L
*IG α-L
-
**[[4ixd]] – hIG I domain<br />
+
**[[1lfa]] - hIG I domain + Mn <br />
 +
**[[1zon]], [[4ixd]], [[7kc3]] - hIG I domain 153-334 <br />
 +
**[[1mqa]] - hIG I domain (mutant) <br />
 +
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg <br />
 +
**[[1mq9]] - hIG I domain (mutant) + Mn <br />
 +
**[[1mjn]] - hIG I domain (mutant) + Mg <br />
 +
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR <br />
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />
-
*IG α-L β-2
+
*IG α-L complexes
 +
 
 +
**[[1cqp]] - hIG I domain + lovastatin + Mg <br />
 +
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg <br />
 +
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
 +
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
 +
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
 +
**[[1xdd]], [[1xdg]], [[1xuo]], [[7kc5]] - hIG I domain + inhibitor + Mg<br />
 +
**[[7kc6]] - hIG I domain + drug + Mg<br />
 +
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
 +
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
 +
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 +
 
 +
*IG α-L + IG β-2
**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
Line 134: Line 124:
*IG α-M
*IG α-M
 +
**[[1idn]], [[1na5]] - hIG<br />
 +
**[[1mf7]] - hIG (mutant) <br />
 +
**[[1bho]] - hIG + Mg<br />
 +
**[[1bhq]] - hIG + Cd<br />
 +
**[[1m1u]] - hIG (mutant) + Ca<br />
 +
**[[1n9z]] - hIG (mutant) + Mg<br />
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[4m76]] – hIG + complement C3<br />
**[[4m76]] – hIG + complement C3<br />
-
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
+
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<br />
**[[4xw2]] – hIG + simvastatin<br />
**[[4xw2]] – hIG + simvastatin<br />
 +
**[[6rhv]], [[6rhw]] – hIG + cytolysin<br />
 +
 +
*IG α-M + IG β-2
 +
 +
**[[7usm]] – hIG ectodomain – Cryo EM<br />
 +
**[[7usl]] – hIG ectodomain + adenylate cyclase toxin + antibody – Cryo EM<br />
 +
**[[7p2d]] – hIG ectodomain + nanobody <br />
 +
 +
*IG α-V + IG β-3
 +
 +
**[[6mk0]] – hIG + antagonist<br />
 +
**[[6msl]] – hIG + cysteine knot protein<br />
 +
**[[6msu]] – hIG + EETI-II<br />
 +
**[[6naj]] – hIG + fibronectin<br />
-
*IG α-V β-8
+
*IG α-V + IG β-8
-
**[[6djp]] – hIG + antibody – Cryo EM<br />
+
**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />
 +
**[[6om1]] – hIG (mutant)<br />
 +
**[[6om2]] – hIG (mutant) + Protgf-b1 RGD peptide<br />
 +
**[[6uja]] – hIG + Protgf-b1 RGD – Cryo EM<br />
 +
**[[7y1t]] – hIG + TGF-b1 – Cryo EM<br />
*IG α-X
*IG α-X
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
 +
**[[1n3y]] – hIG domain I (mutant)<br />
-
*IG α-X β-2 (CD18)
+
*IG α-X + IG β-2 (CD18)
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
Line 169: Line 184:
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
 +
**[[6bxb]], [[6bxf]] – hIG/hIG α-L <br />
*IG β-4 (CD104; Gp150)
*IG β-4 (CD104; Gp150)

Current revision

3D structures of integrin

Updated on 31-May-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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