S-adenosylhomocysteine hydrolase

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**[[3gvp]] – hAHCH SAHH-like domain + NAD <BR />
**[[3gvp]] – hAHCH SAHH-like domain + NAD <BR />
**[[3d64]] – BpAHCH + NAD – ''Burkholderia pseudmallei''<BR />
**[[3d64]] – BpAHCH + NAD – ''Burkholderia pseudmallei''<BR />
 +
**[[3x2f]] – AHCH + NADH – ''Thermotoga maritima''<BR />
*S-adenosylhomocysteine hydrolase complex with adenosine derivatives
*S-adenosylhomocysteine hydrolase complex with adenosine derivatives
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**[[5m5k]] – BeAHCH + NAD + adenosine + cordycepin<BR />
**[[5m5k]] – BeAHCH + NAD + adenosine + cordycepin<BR />
**[[5m67]] – BeAHCH + NAD + adenosine + deoxyadenine<BR />
**[[5m67]] – BeAHCH + NAD + adenosine + deoxyadenine<BR />
 +
**[[3g1u]] – AHCH + NAD + adenosine – ''Leishmania major''<BR />
*S-adenosylhomocysteine hydrolase other complexes
*S-adenosylhomocysteine hydrolase other complexes
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<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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[[Category:One-carbon metabolism]]

Current revision

Structure of rat S-adenosylhomocysteine hydrolase tetramer complex with NAD and adenine (PDB entry 1xwf)

Drag the structure with the mouse to rotate

3D structures of S-adenosylhomocysteine hydrolase

Updated on 14-November-2023

References

  1. Altintas E, Sezgin O. S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia. Med Hypotheses. 2004;63(5):834-7. PMID:15488656 doi:http://dx.doi.org/10.1016/j.mehy.2004.03.031
  2. Baric I, Fumic K, Glenn B, Cuk M, Schulze A, Finkelstein JD, James SJ, Mejaski-Bosnjak V, Pazanin L, Pogribny IP, Rados M, Sarnavka V, Scukanec-Spoljar M, Allen RH, Stabler S, Uzelac L, Vugrek O, Wagner C, Zeisel S, Mudd SH. S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4234-9. Epub 2004 Mar 15. PMID:15024124 doi:10.1073/pnas.0400658101
  3. Yamada T, Takata Y, Komoto J, Gomi T, Ogawa H, Fujioka M, Takusagawa F. Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89. Int J Biochem Cell Biol. 2005 Nov;37(11):2417-35. PMID:16061414 doi:10.1016/j.biocel.2005.06.009

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Michal Harel, Alexander Berchansky, Karsten Theis, Joel L. Sussman

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