Selenocysteine synthase
From Proteopedia
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<StructureSection load='3hl2' size='350' side='right' caption='Human selenocysteine synthase containing phosphoserine complex with tRNASec, monothiophosphate, deoxypyridoxine phosphate (PDB entry [[3hl2]])' scene='46/468224/Cv/1'> | <StructureSection load='3hl2' size='350' side='right' caption='Human selenocysteine synthase containing phosphoserine complex with tRNASec, monothiophosphate, deoxypyridoxine phosphate (PDB entry [[3hl2]])' scene='46/468224/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Selenocysteine synthase''' (SecS) converts phospho-seryl-tRNA (tRNASec) into selenocysteinyl-tRNA using selenophosphate as the Se donor<ref>PMID:1839607</ref>. | + | '''Selenocysteine synthase''' or '''O-phosphoseryl-tRNA(Sec) selenium transfrase''' (SecS) converts phospho-seryl-tRNA (tRNASec) into selenocysteinyl-tRNA using selenophosphate as the Se donor<ref>PMID:1839607</ref>. |
== Disease == | == Disease == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | [[4zdl]] – hSecS (mutant) - human<br /> | ||
| + | [[3hl2]] - hSecS + tRNASec <br /> | ||
| + | [[4zdo]], [[4zdp]] – hSecS (mutant) + tRNASec<br /> | ||
| + | [[7l1t]] – hSecS + pyridoxine derivative <br /> | ||
[[3bc8]], [[3bca]] - mSecS elastase-resistant fragment - mouse | [[3bc8]], [[3bca]] - mSecS elastase-resistant fragment - mouse | ||
| Line 19: | Line 23: | ||
[[2z67]] - SecS - ''Methanococcus maripaludis'' | [[2z67]] - SecS - ''Methanococcus maripaludis'' | ||
| - | [[3hl2]] - hSecS + tRNASec + PLP - human<br /> | ||
| - | [[4zdl]] – hSecS (mutant) <br /> | ||
| - | [[4zdo]], [[4zdp]] – hSecS (mutant) + tRNASec<br /> | ||
[[3w1i]] – AaSecS + pyridine derivative – ''Aquifex aeolicus''<br /> | [[3w1i]] – AaSecS + pyridine derivative – ''Aquifex aeolicus''<br /> | ||
[[3wcn]] – AaSecS (mutant) <br /> | [[3wcn]] – AaSecS (mutant) <br /> | ||
Current revision
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3D Structures of selenocysteine synthase
Updated on 15-March-2022
4zdl – hSecS (mutant) - human
3hl2 - hSecS + tRNASec
4zdo, 4zdp – hSecS (mutant) + tRNASec
7l1t – hSecS + pyridoxine derivative
3bc8, 3bca - mSecS elastase-resistant fragment - mouse
3bcb - mSecS elastase-resistant fragment + phosphate
2z67 - SecS - Methanococcus maripaludis
3w1i – AaSecS + pyridine derivative – Aquifex aeolicus
3wcn – AaSecS (mutant)
3w1h, 3wco – AaSecS (mutant) + pyridine derivative
3w1j – AaSecS + pyridine derivative
3w1k – AaSecS (mutant) + pyridine derivative + tRNASec
References
- ↑ Forchhammer K, Boesmiller K, Bock A. The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine. Biochimie. 1991 Dec;73(12):1481-6. PMID:1839607
- ↑ Schweizer U, Dehina N, Schomburg L. Disorders of selenium metabolism and selenoprotein function. Curr Opin Pediatr. 2011 Aug;23(4):429-35. doi: 10.1097/MOP.0b013e32834877da. PMID:21670677 doi:http://dx.doi.org/10.1097/MOP.0b013e32834877da
- ↑ Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M. The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. Science. 2009 Jul 17;325(5938):321-5. PMID:19608919 doi:325/5938/321
