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Isocitrate dehydrogenase 3D structures

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(New page: ==3D Structures of Isocitrate dehydrogenase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Isocitrate dehydroge...)
Current revision (08:55, 12 June 2023) (edit) (undo)
 
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Line 6: Line 6:
*Isocitrate dehydrogenase
*Isocitrate dehydrogenase
-
**[[5grh]] – hIDH3 α,γ subunits + Mg - human<br />
+
**[[6kdf]] – hIDH3 α,β subunits - human<br />
 +
**[[8grb]], [[8gs5]] – hIDH3 a (mutant),b subunits <br />
 +
**[[6kde]] – hIDH3 a,b subunits + Ca <br />
 +
**[[8grg]] – hIDH3 a,g subunits <br />
 +
**[[5grh]] – hIDH3 α,γ subunits + Mg <br />
 +
**[[7ce3]] – hIDH3 α,β,γ subunits<br />
**[[3blx]] – yIDH - yeast<br />
**[[3blx]] – yIDH - yeast<br />
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
Line 22: Line 27:
**[[5z16]] – IDH –'' Acinetobacter baumannii''<br />
**[[5z16]] – IDH –'' Acinetobacter baumannii''<br />
**[[5m2e]] - PaIDH – ''Pseudomonas aeruginosa''<br />
**[[5m2e]] - PaIDH – ''Pseudomonas aeruginosa''<br />
 +
**[[6ixl]] – OtIDH – ''Ostreococcus tauri''<br />
 +
**[[6lkz]] – IDH – ''Phaeodactylum tricomutum''<br />
 +
**[[6ltf]], [[6m3s]] – IDH – ''Xanthomonas campestris''<br />
*IDH+citrate
*IDH+citrate
**[[5yfn]] – hIDH1 + isocitrate+ Mg<br />
**[[5yfn]] – hIDH1 + isocitrate+ Mg<br />
-
**[[5gri]] – hIDH3 a,g subunits + citrate+ Mg<br />
+
**[[5gri]] – hIDH3 α,γ subunits + citrate+ Mg<br />
 +
**[[8grh]] – hIDH3 a (mutant),g subunits + citrate<br />
 +
**[[5h3f]] – mIDH 2 + isocitrate<br />
 +
**[[5h3e]] – mIDH 2 (mutant) + isocitrate<br />
**[[2qfw]] – yIDH+isocitrate <br />
**[[2qfw]] – yIDH+isocitrate <br />
**[[3blv]] – yIDH+citrate<br />
**[[3blv]] – yIDH+citrate<br />
Line 38: Line 49:
**[[1hqs]] – IDH+citrate – ''Bacillus subtilis''<br />
**[[1hqs]] – IDH+citrate – ''Bacillus subtilis''<br />
**[[4zda]] - IDH +isocitrate+Mn – ''Mycobacterium smegmatis''<br />
**[[4zda]] - IDH +isocitrate+Mn – ''Mycobacterium smegmatis''<br />
 +
**[[7e2w]] - OtIDH +isocitrate+Mg<br />
*IDH+NADP
*IDH+NADP
-
**[[1t09]] – hIDH+NADP <br />
+
**[[1t09]], [[5yfm]] – hIDH+NADP <br />
**[[3mar]] – hIDH (mutant) + NADP<br />
**[[3mar]] – hIDH (mutant) + NADP<br />
**[[5k10]], [[5k11]] – hIDH + NADP – Cryo EM<br />
**[[5k10]], [[5k11]] – hIDH + NADP – Cryo EM<br />
**[[5svn]], [[5svo]] – hIDH2 (mutant) + NADP<br />
**[[5svn]], [[5svo]] – hIDH2 (mutant) + NADP<br />
 +
**[[6kdy]], [[6ke3]] – hIDH3 α,β + NADH<br />
**[[5yvt]] – hIDH α+γ + NADH<br />
**[[5yvt]] – hIDH α+γ + NADH<br />
**[[5yzh]] – mIDH+NADP – mouse<br />
**[[5yzh]] – mIDH+NADP – mouse<br />
Line 56: Line 69:
**[[4hcx]], [[5kvu]] – IDH + NADP – ''mycobacterium tuberculosis''<br />
**[[4hcx]], [[5kvu]] – IDH + NADP – ''mycobacterium tuberculosis''<br />
**[[6aj6]] – TbIDH (mutant) + NADP – ''Trypanosoma brucei''<br />
**[[6aj6]] – TbIDH (mutant) + NADP – ''Trypanosoma brucei''<br />
 +
**[[6ixt]] – OtIDH + NAD + Mg<br />
*IDH+α-ketoglutarate
*IDH+α-ketoglutarate
Line 72: Line 86:
**[[6aj8]], [[6aja]], [[6ajb]] - TbIDH (mutant) +NADP + α-ketoglutarate <br />
**[[6aj8]], [[6aja]], [[6ajb]] - TbIDH (mutant) +NADP + α-ketoglutarate <br />
-
*IDH binary complex
+
*IDH binary complex with inhibitor
-
**[[5yfm]] – hIDH1 + isocitrate<br />
+
**[[6q6f]] – hIDH1 (mutant) + inhibitor<br />
-
**[[5h3f]] – mIDH 2 + isocitrate<br />
+
-
**[[5h3e]] – mIDH 2 (mutant) + isocitrate<br />
+
**[[3asj]] – TtIDH + inhbibitor<br />
**[[3asj]] – TtIDH + inhbibitor<br />
*IDH higher complexes
*IDH higher complexes
-
**[[3map]] - hIDH+NADP+isocitrate<br />
+
**[[3map]], [[6pay]] - hIDH1 +NADP+isocitrate<br />
-
**[[3mas]] – hIDH (mutant) +NADP+isocitrate<br />
+
**[[3mas]] – hIDH1 (mutant) +NADP+isocitrate<br />
**[[1t0l]] – hIDH+NADP+isocitrate+Ca<br />
**[[1t0l]] – hIDH+NADP+isocitrate+Ca<br />
**[[5gre]], [[5grf]] – hIDH3 α,γ subunits + ADP+ citrate+ Mg<br />
**[[5gre]], [[5grf]] – hIDH3 α,γ subunits + ADP+ citrate+ Mg<br />
**[[5grl]] – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg<br />
**[[5grl]] – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg<br />
-
**[[5l57]], [[5l58]] - hIDH +NADP + inhibitor<br />
+
**[[5l57]], [[5l58]] - hIDH1 +NADP + inhibitor<br />
-
**[[4i3k]], [[4i3l]], [[4ja8]],[[4umx]], [[4umy]], [[4xrx]], [[4xs3]], [[5de1]], [[5lge]], [[5sun]], [[5svf]], [[6b0z]], [[5tqh]], [[6o2y]], [[6o2z]], [[6adg]] - hIDH1 (mutant) +NADP + inhibitor<br />
+
**[[4i3k]], [[4i3l]], [[4ja8]],[[4umx]], [[4umy]], [[4xrx]], [[4xs3]], [[5de1]], [[5lge]], [[5sun]], [[5svf]], [[6b0z]], [[5tqh]], [[6o2y]], [[6o2z]], [[6adg]], [[6u4j]], [[6vei]], [[6vg0]] - hIDH1 (mutant) +NADP + inhibitor<br />
-
**[[6adi]] – hIDH2 (mutant) +NADP + inhibitor<br />
+
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] – hIDH1 + isocitrate + inhibitor<br />
-
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] - hIDH + isocitrate + inhibitor<br />
+
**[[6adi]], [[6vfz]] – hIDH2 (mutant) +NADP + inhibitor<br />
 +
**[[6l57]], [[6l59]] – hIDH3 a+g + citrate + ATP<br />
 +
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] - hIDH1 + isocitrate + inhibitor<br />
 +
**[[8bay]] – hIDH1 (mutant) + NADP + butyloxoglutarate <br />
 +
**[[7pjn]], [[8hb9]] – hIDH1 (mutant) +NADP + inhibitor<br />
 +
**[[8grd]] – hIDH3 a+b + ADP + Mg<br />
**[[5svf]] - hIDH (mutant) +NADP + citrate + inhibitor<br />
**[[5svf]] - hIDH (mutant) +NADP + citrate + inhibitor<br />
**[[5i96]] – hIDH2 + NADP+ enasidenib + Ca<br />
**[[5i96]] – hIDH2 + NADP+ enasidenib + Ca<br />
Line 99: Line 116:
**[[1idc]] - EcIDH (mutant)+oxalosuccinate+Mg<br />
**[[1idc]] - EcIDH (mutant)+oxalosuccinate+Mg<br />
**[[6ajc]] - TbIDH (mutant) +NADP+isocitrate<br />
**[[6ajc]] - TbIDH (mutant) +NADP+isocitrate<br />
 +
**[[6ixn]] - OtIDH +NAD + citrate<br />
*IDH quaternary complexes
*IDH quaternary complexes
-
**[[5svf]] – hIDH1 (mutant) +NADP + citrate + inhibitor<br />
+
**[[5svf]], [[6io0]] – hIDH1 (mutant) +NADP + citrate + inhibitor<br />
 +
**[[8gru]] – hIDH1 (mutant) +NAD + isocitrate + Ca<br />
 +
**[[7pjm]] – hIDH1 (mutant) +NADP + oxoglutarate + Ca<br />
**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
Line 111: Line 131:
**[[3lcb]] - EcIDH + IDH kinase/phosphatase + AMP + ATP<br />
**[[3lcb]] - EcIDH + IDH kinase/phosphatase + AMP + ATP<br />
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
-
**[[4aov]] - DpIDH + isocitrate+NADP+Mg
+
**[[4aov]] - DpIDH + isocitrate+NADP+Mg<br />
 +
**[[7e3n]] - TbIDH (mutant) +NADP + α-ketoglutarate + Ca<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Isocitrate dehydrogenase

Updated on 12-June-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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