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Succinate-semialdehyde dehydrogenase

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== Function ==
== Function ==
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'''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>.
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'''Succinate-semialdehyde dehydrogenase''' or '''α-ketoglutaric semialdehyde dehydrogenase''' or '''succinyl-CoA reductase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. See also [[Aldehyde dehydrogenase]].
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== Disease ==
== Disease ==
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*Succinate-semialdehyde dehydrogenase
*Succinate-semialdehyde dehydrogenase
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**[[2w8n]], [[2w8o]] – hSSD - human <br />
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**[[2w8p]] – hSSD (mutant) <br />
**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br />
**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br />
**[[3vz2]] – SySSD (mutant) <br />
**[[3vz2]] – SySSD (mutant) <br />
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**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br />
**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br />
**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br />
**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br />
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**[[2w8n]], [[2w8o]] – hSSD - human <br />
 
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**[[2w8p]] – hSSD (mutant) <br />
 
**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br />
**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br />
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**[[5x5t]] – AbSSD – ''Azuspirillum brasilense'' <br />
*Succinate-semialdehyde dehydrogenase complexes
*Succinate-semialdehyde dehydrogenase complexes
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**[[4oht]] – SpSSD + NADPH<br />
**[[4oht]] – SpSSD + NADPH<br />
**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br />
**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br />
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**[[5x5u]] – AbSSD + NAD<br />
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**[[8c54]] – SSD + NADH – ''Rhizobium leguminosarum'' – Cryo EM<br />
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**[[8cej]] – CkSSD + mesaconyl-c1-CoA – ''Clostridium kluyveri''<br />
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**[[8cek]] – CkSSD + NADPH<br />
}}
}}

Current revision

Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3).

Drag the structure with the mouse to rotate

3D structures of succinate-semialdehyde dehydrogenase

Updated on 06-December-2023

References

  1. ↑ JAKOBY WB, SCOTT EM. Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem. 1959 Apr;234(4):937-40. PMID:13654295
  2. ↑ Gordon N. Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria). Eur J Paediatr Neurol. 2004;8(5):261-5. PMID:15341910 doi:http://dx.doi.org/10.1016/j.ejpn.2004.06.004
  3. ↑ Yuan Z, Yin B, Wei D, Yuan YR. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase. J Struct Biol. 2013 May;182(2):125-35. doi: 10.1016/j.jsb.2013.03.001. Epub 2013 , Mar 13. PMID:23500184 doi:10.1016/j.jsb.2013.03.001

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