Survivin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Survivin''' or '''apoptosis inhibitor 4''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>. Survivin is part of the chromosomal passanger complex (CPC) which includes also [[Borealin]] and [[INCENP]] <ref>PMID:23175282</ref>. | + | '''Survivin''' or '''apoptosis inhibitor 4''' or '''baculoviral IAP repeat-containing protein 5''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>. Survivin is part of the chromosomal passanger complex (CPC) which includes also [[Borealin]] and [[INCENP]] <ref>PMID:23175282</ref>. |
== Disease == | == Disease == | ||
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*Survivin | *Survivin | ||
| - | **[[1e31]] – hIAP4 – human<br /> | + | **[[1e31]], [[6sho]] – hIAP4 – human<br /> |
**[[1f3h]], [[3ueg]], [[3ueh]], [[3uei]] – hIAP4 (mutant) <br /> | **[[1f3h]], [[3ueg]], [[3ueh]], [[3uei]] – hIAP4 (mutant) <br /> | ||
**[[1xox]] – hIAP4 – NMR<br /> | **[[1xox]] – hIAP4 – NMR<br /> | ||
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**[[2raw]], [[2rax]] – hIAP4 + Borealin N-terminal<br /> | **[[2raw]], [[2rax]] – hIAP4 + Borealin N-terminal<br /> | ||
| - | **[[2qfa]] – hIAP4 + Borealin N-terminal + inner centromere protein<br /> | + | **[[2qfa]], [[6yie]] – hIAP4 + Borealin N-terminal + inner centromere protein<br /> |
| + | **[[6yif]], [[6yih]] – hIAP4 + Borealin N-terminal + inner centromere protein + histone H3 peptide<br /> | ||
**[[4a0i]] – hIAP4 + shugoshin peptide<br /> | **[[4a0i]] – hIAP4 + shugoshin peptide<br /> | ||
| - | **[[4a0j]], [[4a0n]], [[3uig]], [[3uii]], [[3ued]] – hIAP4 + histone H3 peptide<br /> | + | **[[4a0j]], [[4a0n]], [[3uig]], [[3uii]], [[3ued]], [[7lbk]], [[7lbo]], [[7lbp]], [[7lbq]] – hIAP4 + histone H3 peptide<br /> |
**[[3uik]], [[3uec]], [[3uee]], [[3uef]] – hIAP4 (mutant) + histone H3 peptide<br /> | **[[3uik]], [[3uec]], [[3uee]], [[3uef]] – hIAP4 (mutant) + histone H3 peptide<br /> | ||
**[[3uih]] – hIAP4 + diablo peptide<br /> | **[[3uih]] – hIAP4 + diablo peptide<br /> | ||
Current revision
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3D structures of survivin
Updated on 14-April-2022
References
- ↑ Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056
- ↑ Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. PMID:23175282 doi:http://dx.doi.org/10.1038/nrm3474
- ↑ Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822
- ↑ Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927
