T-cell receptor

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<StructureSection load='' size='350' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>
<StructureSection load='' size='350' side='right' scene='53/536684/Cv/1' caption='T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].'>
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__TOC__
== Function ==
== Function ==
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'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells.
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'''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of '''α+β subunits''' and ca. 5% the T cells have '''γ+δ subumits'''. '''TCR NKT''' reside in Natural Killer T-cells.
*<scene name='53/536684/Cv/3'>T-cell receptor α chain, β chain complex with enterotoxin and Na+ ion</scene> ([[2xna]]).
*<scene name='53/536684/Cv/3'>T-cell receptor α chain, β chain complex with enterotoxin and Na+ ion</scene> ([[2xna]]).
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== Relevance ==
== Relevance ==
Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.
Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy.
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</StructureSection>
 
== 3D structures of T-cell receptor==
== 3D structures of T-cell receptor==
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[[T-cell receptor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*TCR α chain
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**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
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**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br />
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**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br />
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*TCR β chain
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**[[1bec]] – mTCR β chain <br />
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**[[2axh]] – hTCR β chain (mutant) <br />
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**[[2axj]] – hTCR β chain <br />
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**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />
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*TCR β chain + antigen
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**[[1jck]], [[1sbb]], [[1l0x]], [[1l0y]], [[2aq1]], [[2aq2]], [[2aq3]], [[3mc0]] – mTCR β chain (mutant) + antigen<br />
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**[[1ktk]], [[3byt]], [[3byy]], [[3bzd]] – hTCR β chain (mutant) + exotoxin type C <br />
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**[[2ij0]] – hTCR β chain + toxic shock syndrome toxin-1 <br />
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*TCR δ chain
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**[[1tvd]] – hTCR δ chain variable domain <br />
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*TCR α+β chains
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**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />
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**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />
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**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />
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**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]], [[6eh4]], [[6eh5]], [[6eh6]], [[6eh7]], [[6eh8]], [[6eh9]], [[6fr6]], [[6fr7]], [[6fr8]], [[6fr9]], [[6fra]], [[6frb]], [[6frc]], [[6fum]], [[6fun]], [[6fuo]], [[6fup]], [[6fuq]], [[6fur]], [[6at6]], [[6fr3]], [[6fr4]], [[6fr5]] – hTCR α+β chains<br />
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**[[4ei6]] – h/mTCR α+β chains <br />
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**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
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**[[3of6]] – hTCR pre-α+β (mutant) chains<br />
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*TCR α+β+γ chains
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**[[4mnh]] – hTCR α+β+γ chains<br />
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*TCR γ+δ chains
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**[[1hxm]], [[3omz]] – hTCR γ+δ chains<br />
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**[[4ndm]] – hTCR γ+δ chains (mutant)<br />
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*TCR complex with antigen
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**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />
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**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br />
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**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br />
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*TCR complex with MHC and antigen
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**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]], [[6at5]], [[6avf]], [[6avg]], [[6bj2]], [[6bj3]], [[6bj8]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
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**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />
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**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />
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**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
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**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br />
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**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />
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**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />
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**[[3t0e]] – hTCR α+β chains + MHC + CD4 <br />
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**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
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**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
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**[[5xov]], [[5xot]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />
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**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
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**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
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**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
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**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
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**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br />
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**[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]], [[6bga]] – mTCR α+β chains + MHC + polypeptide <br />
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**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br />
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**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />
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*TCR complex with CD1
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**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />
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**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />
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**[[6c09]] – hTCR α+β chains + β-2 microglobulin + CD1C <br />
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**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
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**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />
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**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
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**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) 2xna.

Drag the structure with the mouse to rotate

References

  1. ↑ Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, Nagy LE. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res. 2007 Sep;31(9):1581-8. Epub 2007 Jul 11. PMID:17624994 doi:http://dx.doi.org/10.1111/j.1530-0277.2007.00452.x
  2. ↑ Uttenthal BJ, Chua I, Morris EC, Stauss HJ. Challenges in T cell receptor gene therapy. J Gene Med. 2012 Jun;14(6):386-99. doi: 10.1002/jgm.2637. PMID:22610778 doi:http://dx.doi.org/10.1002/jgm.2637

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