6kux
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6kux is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structures of the alpha2A adrenergic receptor in complex with an antagonist RSC.== | |
| + | <StructureSection load='6kux' size='340' side='right'caption='[[6kux]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6kux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KUX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E3F:(8~{a}~{R},12~{a}~{S},13~{a}~{S})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,11,12~{a},13,13~{a}-decahydroisoquinolino[2,1-g][1,6]naphthyridine'>E3F</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kux OCA], [https://pdbe.org/6kux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kux RCSB], [https://www.ebi.ac.uk/pdbsum/6kux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kux ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ADA2A_HUMAN ADA2A_HUMAN] Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.<ref>PMID:23105096</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Qu L]] | ||
| + | [[Category: Wu D]] | ||
| + | [[Category: Zhao SW]] | ||
| + | [[Category: Zhou QT]] | ||
Current revision
Crystal structures of the alpha2A adrenergic receptor in complex with an antagonist RSC.
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Categories: Homo sapiens | Large Structures | Qu L | Wu D | Zhao SW | Zhou QT
