6kwx

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m (Protected "6kwx" [edit=sysop:move=sysop])
Current revision (10:44, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6kwx is ON HOLD
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==cryo-EM structure of human PA200==
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<StructureSection load='6kwx' size='340' side='right'caption='[[6kwx]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
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Authors: Ouyang, S., Hongxin, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6kwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KWX FirstGlance]. <br>
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Description: cryo-EM structure of human PA200
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=K0W:[(1~{S},2~{R},3~{R},4~{S},5~{S},6~{R})-2-[oxidanyl(phosphonooxy)phosphoryl]oxy-3,4,5,6-tetraphosphonooxy-cyclohexyl]+phosphono+hydrogen+phosphate'>K0W</scene></td></tr>
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[[Category: Ouyang, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kwx OCA], [https://pdbe.org/6kwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kwx RCSB], [https://www.ebi.ac.uk/pdbsum/6kwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kwx ProSAT]</span></td></tr>
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[[Category: Hongxin, G]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSME4_HUMAN PSME4_HUMAN] Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.<ref>PMID:12093752</ref> <ref>PMID:18845680</ref> <ref>PMID:22550082</ref> <ref>PMID:23706739</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hongxin G]]
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[[Category: Ouyang S]]

Current revision

cryo-EM structure of human PA200

PDB ID 6kwx

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