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6kzc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide== | |
| + | <StructureSection load='6kzc' size='340' side='right'caption='[[6kzc]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6kzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KZC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DZC:3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide'>DZC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kzc OCA], [https://pdbe.org/6kzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kzc RCSB], [https://www.ebi.ac.uk/pdbsum/6kzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kzc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NTRK3_HUMAN NTRK3_HUMAN] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. | ||
| - | + | ==See Also== | |
| - | + | *[[TrkB tyrosine kinase receptor|TrkB tyrosine kinase receptor]] | |
| - | + | *[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Wang | + | </StructureSection> |
| - | [[Category: Zhang | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Zhang ZM]] | ||
Current revision
crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide
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