6pww
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome== | |
| + | <SX load='6pww' size='340' side='right' viewer='molstar' caption='[[6pww]], [[Resolution|resolution]] 4.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6pww]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PWW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pww OCA], [https://pdbe.org/6pww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pww RCSB], [https://www.ebi.ac.uk/pdbsum/6pww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pww ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RBBP5_HUMAN RBBP5_HUMAN] In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.<ref>PMID:19556245</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | [[Category: | + | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] |
| + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Ayoub A]] | ||
| + | [[Category: Cho U]] | ||
| + | [[Category: Cianfrocco MA]] | ||
| + | [[Category: Dou Y]] | ||
| + | [[Category: Lee YT]] | ||
| + | [[Category: Park SH]] | ||
| + | [[Category: Su M]] | ||
| + | [[Category: Xu J]] | ||
| + | [[Category: Zhang B]] | ||
| + | [[Category: Zhang W]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome
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Categories: Homo sapiens | Large Structures | Synthetic construct | Xenopus laevis | Ayoub A | Cho U | Cianfrocco MA | Dou Y | Lee YT | Park SH | Su M | Xu J | Zhang B | Zhang W | Zhang Y
