6sx3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6sx3 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Intercalation of heterocyclic ligand between quartets in G-rich tetrahelical structure== | |
| + | <StructureSection load='6sx3' size='340' side='right'caption='[[6sx3]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6sx3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SX3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LWQ:~{N}2,~{N}6-bis(1-methylquinolin-1-ium-3-yl)pyridine-2,6-dicarboxamide'>LWQ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sx3 OCA], [http://pdbe.org/6sx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sx3 RCSB], [http://www.ebi.ac.uk/pdbsum/6sx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sx3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | G-rich oligonucleotide VK2 folds into an AGCGA-quadruplex, tetrahelical structure distinct and significantly different from G-quadruplexes, even though it contains four G3-tracts. Herein, we show that a bis-quinolinium ligand 360A with high affinity for G-quadruplex structures and selective telomerase inhibition, strongly binds to VK2. Upon binding, 360A does not induce a conformational switch from VK2 to an expected G-quadruplex. In contrast, NMR structural study revealed formation of a well-defined VK2-360A complex with a 1:1 binding stoichiometry, where 360A intercalates between GAGA- and GCGC-quartets in the central cavity of VK2. This is the first high-resolution structure of a G-quadruplex ligand intercalating into a G-rich tetrahelical fold. Unique mode of ligand binding into tetrahelical DNA architecture offers insights into stabilization of an AGCGA-quadruplex by a heterocyclic ligand and provides guidelines for rational design of novel VK2 binding molecules with selectivity for different DNA secondary structures. | ||
| - | + | Intercalation of heterocyclic ligand between quartets in G-rich tetrahelical structure.,Plavec J, Kocman V, Kotar A Chemistry. 2019 Nov 21. doi: 10.1002/chem.201904923. PMID:31750579<ref>PMID:31750579</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6sx3" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kocman, V]] | ||
| + | [[Category: Kotar, A]] | ||
| + | [[Category: Plavec, J]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Intercalation agcga-quadruplex g-quadruplex heterocyclic ligand]] | ||
Current revision
Intercalation of heterocyclic ligand between quartets in G-rich tetrahelical structure
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