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6ucd

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(New page: '''Unreleased structure''' The entry 6ucd is ON HOLD Authors: Patel, D., Young, P.G., Bunker, R.D., Baker, E.N., Fraser, J.D. Description: The crystal structure of Staphylococcus aureu...)
Current revision (07:49, 11 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6ucd is ON HOLD
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==The crystal structure of Staphylococcus aureus super antigen-like protein SSL10==
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<StructureSection load='6ucd' size='340' side='right'caption='[[6ucd]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ucd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ucd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucd OCA], [https://pdbe.org/6ucd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ucd RCSB], [https://www.ebi.ac.uk/pdbsum/6ucd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSL10_STAA8 SSL10_STAA8] Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).<ref>PMID:19308288</ref> <ref>PMID:19913916</ref> <ref>PMID:23754290</ref> <ref>PMID:28193526</ref>
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Authors: Patel, D., Young, P.G., Bunker, R.D., Baker, E.N., Fraser, J.D.
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==See Also==
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*[[Exotoxin 3D structures|Exotoxin 3D structures]]
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Description: The crystal structure of Staphylococcus aureus super antigen-like protein SSL10
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Fraser, J.D]]
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__TOC__
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[[Category: Bunker, R.D]]
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</StructureSection>
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[[Category: Baker, E.N]]
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[[Category: Large Structures]]
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[[Category: Patel, D]]
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[[Category: Staphylococcus aureus]]
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[[Category: Young, P.G]]
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[[Category: Baker EN]]
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[[Category: Bunker RD]]
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[[Category: Fraser JD]]
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[[Category: Patel D]]
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[[Category: Young PG]]

Current revision

The crystal structure of Staphylococcus aureus super antigen-like protein SSL10

PDB ID 6ucd

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