6rty

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<StructureSection load='6rty' size='340' side='right'caption='[[6rty]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6rty' size='340' side='right'caption='[[6rty]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rty]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RTY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RTY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rty OCA], [http://pdbe.org/6rty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rty RCSB], [http://www.ebi.ac.uk/pdbsum/6rty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rty ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rty OCA], [https://pdbe.org/6rty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rty RCSB], [https://www.ebi.ac.uk/pdbsum/6rty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rty ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Semilobar holoprosencephaly;Monosomy 9q22.3;Alobar holoprosencephaly;Microform holoprosencephaly;Septopreoptic holoprosencephaly;Gorlin syndrome;Lobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
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[https://www.uniprot.org/uniprot/PTC1_HUMAN PTC1_HUMAN] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6rty" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6rty" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein patched homolog 1|Protein patched homolog 1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ansell, T B]]
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[[Category: Ansell TB]]
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[[Category: Bishop, B]]
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[[Category: Bishop B]]
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[[Category: Covey, D F]]
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[[Category: Covey DF]]
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[[Category: Duman, R]]
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[[Category: Duman R]]
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[[Category: Kinnebrew, M]]
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[[Category: El Omari K]]
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[[Category: Kowatsch, C]]
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[[Category: Kinnebrew M]]
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[[Category: Malinauskas, T]]
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[[Category: Kowatsch C]]
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[[Category: Omari, K El]]
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[[Category: Malinauskas T]]
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[[Category: Pardon, E]]
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[[Category: Pardon E]]
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[[Category: Qian, M]]
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[[Category: Qian M]]
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[[Category: Rohatgi, R]]
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[[Category: Rohatgi R]]
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[[Category: Rudolf, A F]]
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[[Category: Rudolf AF]]
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[[Category: Sansom, M S.P]]
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[[Category: Sansom MSP]]
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[[Category: Schwab, R A]]
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[[Category: Schwab RA]]
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[[Category: Siebold, C]]
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[[Category: Siebold C]]
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[[Category: Steyaert, J]]
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[[Category: Steyaert J]]
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[[Category: Wagner, A]]
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[[Category: Wagner A]]
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[[Category: Hedgehog morphogen receptor]]
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[[Category: Cholesterol]]
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[[Category: Lipid-protein-modification]]
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[[Category: Membrane protein]]
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[[Category: Palmitate]]
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[[Category: Receptor-nanobody complex]]
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Current revision

Crystal structure of the Patched ectodomain in complex with nanobody NB64

PDB ID 6rty

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