TRNA methyltransferase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:26, 10 March 2020) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 7: Line 7:
== Structural highlights ==
== Structural highlights ==
Trm <scene name='55/553109/Cv/4'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. Water molecules are shown as red spheres.
Trm <scene name='55/553109/Cv/4'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. Water molecules are shown as red spheres.
-
</StructureSection>
 
- 
==3D structures of tRNA methyltransferase==
==3D structures of tRNA methyltransferase==
 +
[[tRNA methyltransferase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*'''tRNA guanine 9 N1 methyltransferase'''
+
-
 
+
-
**[[4jwg]] – fyTrm – fission yeast<br />
+
-
**[[4jwf]], [[4jwh]] – fyTrm + SAH <br />
+
-
**[[4jwj]] – yTrm + SAH – yeast<br />
+
-
 
+
-
*'''tRNA guanine 37 N1 methyltransferase'''
+
-
 
+
-
**[[3knu]] – ApTrm – ''Anaplasma phagocytophilum'' <br />
+
-
**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br />
+
-
**[[3ief]] – Trm – ''Bartonella henselae'' <br />
+
-
**[[1uaj]] – HiTrm – ''haemophilus influenzae''<br />
+
-
**[[3ky7]] – Trm – ''Staphylococcus aureus''<br />
+
-
**[[3quv]] – Trm – ''Mycobacterium abscessus''<br />
+
-
**[[5hjj]], [[5yac]] – PaTrm – ''Pyrococcus abyssi''<br />
+
-
 
+
-
*Complexes of tRNA guanine 37 N1 methyltransferase
+
-
 
+
-
**[[1uak]], [[4yvg]] – HiTrm + SAM <br />
+
-
**[[1ual]], [[1uam]] – HiTrm + SAH <br />
+
-
**[[3axz]] – HiTrm + adenosine<br />
+
-
**[[4mcb]], [[4mcc]], [[4mcd]] – HiTrm + inhibitor<br />
+
-
**[[4yvh]] – HiTrm + SFG <br />
+
-
**[[4yvi]], [[4yvj]], [[4yvk]] – HiTrm + SFG + tRNA<br />
+
-
**[[5d9f]], [[4ypw]], [[4ypx]], [[4ypy]], [[4ypz]], [[4yq0]], [[4yq1]], [[4yq2]], [[4yq3]], [[4yq4]], [[4yq5]], [[4yq6]], [[4yq7]], [[4yq8]], [[4yq9]], [[4yqa]], [[4yqb]], [[4yqc]], [[4yqg]], [[4yqi]], [[4yqj]], [[4yqk]], [[4yql]], [[4yqn]], [[4yqo]], [[4yqp]], [[4yqq]], [[4yqr]], [[4yqs]], [[4yqt]], [[4yqd]] – HiTrm + SAM competitive<br />
+
-
**[[1p9p]] – EcTrm + SAH – ''Escherichia coli'' <br />
+
-
**[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br />
+
-
**[[3ay0]] – MjTrm + adenosine<br />
+
-
**[[4h3y]], [[4h3z]] – Trm + SAH – ''Burkholderia phymatum'' <br />
+
-
**[[4ig6]] – ApTrm + SAH <br />
+
-
**[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br />
+
-
**[[5hr7]] – EcTrm + tRNA-Glu<br />
+
-
**[[5hji]], [[5hjm]] – PaTrm + adenosine derivative<br />
+
-
**[[5hjk]] – PaTrm + SAH <br />
+
-
 
+
-
*'''tRNA guanine 46 N7 methyltransferase'''
+
-
 
+
-
**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br />
+
-
**[[2fca]] – Trm – ''Bacillus subtilis'' <br />
+
-
**[[2vdu]], [[2vdv]] – yTrm <br />
+
-
**[[3dxx]] – EcTrm <br />
+
-
 
+
-
*Complexes of tRNA guanine 46 N7 methyltransferase
+
-
 
+
-
**[[3ckk]] – hTrm + SAM - human<br />
+
-
**[[3dxy]] – EcTrm + SAM <br />
+
-
**[[3dxz]] – EcTrm + SAH <br />
+
-
 
+
-
*Trm to O2 of cytidine 32
+
-
 
+
-
**[[4cnd]] – EcTrm (mutant)<br />
+
-
**[[4xbo]] – EcTrm + SAH<br />
+
-
**[[4cne]] – EcTrm (mutant) + SAH<br />
+
-
 
+
-
*'''tRNA cytidine 34 O2 methyltransferase'''
+
-
 
+
-
**[[3e5y]] – BpTrm – ''Burkholderia pseudomalllei'' <br />
+
-
**[[4jak]], [[4kdz]] – EcTrm <br />
+
-
 
+
-
*Complexes of tRNA cytidine 34 O2 methyltransferase
+
-
 
+
-
**[[4kgn]] – BpTrm + SAH <br />
+
-
**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br />
+
-
**[[1mxi]], [[1im8]] – HiTrm + SAH <br />
+
-
**[[4jal]] – EcTrm + SAH<br />
+
-
 
+
-
*'''tRNA guanine 6 N2 methyltransferase'''
+
-
 
+
-
**[[3tm5]] – PfTrm + SFG – ''Pyrococcvus furiosus''<br />
+
-
**[[3tlj]] – PfTrm + SAH<br />
+
-
**[[3tm4]] – PfTrm + SAM<br />
+
-
 
+
-
*Trm M2G/M22G10
+
-
 
+
-
**[[5e71]] – TkTrm – ''Thermococcvus kodakarensis''<br />
+
-
**[[5e72]] – TkTrm + SAM<br />
+
-
 
+
-
*Trm to N1 of adenine 9
+
-
 
+
-
**[[5a7t]], [[5a7z]] – SaTrm – ''Sulfolobus acidocaldarius''<br />
+
-
**[[4cnf]] – SaTrm (mutant)<br />
+
-
**[[5a7y]] – SaTrm + SAH<br />
+
-
**[[4cng]] – SaTrm (mutant) + SAH<br />
+
-
 
+
-
*'''tRNA adenine 58 N1 methyltransferase'''
+
-
 
+
-
**[[2pwy]] – TtTrm – ''Thermus thermophilus''<br />
+
-
**[[5c0o]], [[5c1i]] – TtTrm (mutant) + SAM<br />
+
-
**[[5eqj]] – yTrm <br />
+
-
**[[5erg]] – yTrm + SAM<br />
+
-
**[[5ccb]], [[5cd1]] – hTrm + SAH + tRNA-Lys<br />
+
-
**[[5ccx]] – hTrm + tRNA-Lys<br />
+
-
 
+
-
*Trm to uracil 34
+
-
 
+
-
**[[4qnx]] – EcTrm <br />
+
-
**[[4qnu]], [[4qnv]] – EcTrm + SAM derivative<br />
+
-
 
+
-
*'''tRNA uracil 54 methyltransferase'''
+
-
 
+
-
**[[3bt7]] – yTrm + RNA<br />
+
-
 
+
-
*Trm9-TRM112
+
-
 
+
-
**[[5cm2]] – Trm – ''Yarrowia lipolytica''<br />
+
-
 
+
-
*Trm dual specificity
+
-
**[[4pl1]], [[4pl2]] – EcTrm (mutant) + SAM<br />
 
-
**[[6ems]], [[6emt]] – TkTrm <br />
 
-
**[[6emu]] – TkTrm + SAM<br />
 
-
**[[6emv]] –TkTrm + SAH<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry 1uak)

Drag the structure with the mouse to rotate

References

  1. ↑ Swinehart WE, Jackman JE. Diversity in mechanism and function of tRNA methyltransferases. RNA Biol. 2015;12(4):398-411. doi: 10.1080/15476286.2015.1008358. PMID:25626150 doi:http://dx.doi.org/10.1080/15476286.2015.1008358
  2. ↑ Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK. Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376 doi:10.1093/emboj/cdg269

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/TRNA_methyltransferase"
Personal tools