6ui9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate== | |
| + | <SX load='6ui9' size='340' side='right' viewer='molstar' caption='[[6ui9]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ui9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UI9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ui9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ui9 OCA], [https://pdbe.org/6ui9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ui9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ui9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ui9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Marmorstein R]] | ||
| + | [[Category: Wei X]] | ||
Current revision
Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate
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