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| | ==STRUCTURE OF BET V 1, NMR, 20 STRUCTURES== | | ==STRUCTURE OF BET V 1, NMR, 20 STRUCTURES== |
| - | <StructureSection load='1btv' size='340' side='right'caption='[[1btv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='1btv' size='340' side='right'caption='[[1btv]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1btv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Betpn Betpn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BTV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1btv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BTV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btv OCA], [http://pdbe.org/1btv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1btv RCSB], [http://www.ebi.ac.uk/pdbsum/1btv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1btv ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1btv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btv OCA], [https://pdbe.org/1btv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1btv RCSB], [https://www.ebi.ac.uk/pdbsum/1btv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1btv ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity). | + | [https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN] May be a general steroid carrier protein (By similarity). |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Betpn]] | + | [[Category: Betula pendula]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Gajhede, M]] | + | [[Category: Gajhede M]] |
| - | [[Category: Larsen, J N]] | + | [[Category: Larsen JN]] |
| - | [[Category: Osmark, P]] | + | [[Category: Osmark P]] |
| - | [[Category: Poulsen, F M]] | + | [[Category: Poulsen FM]] |
| - | [[Category: Spangfort, M D]] | + | [[Category: Spangfort MD]] |
| - | [[Category: Ige-allergy]]
| + | |
| - | [[Category: Major birch pollen allergen]]
| + | |
| - | [[Category: Pr-10 protein]]
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| Structural highlights
Function
BEV1A_BETPN May be a general steroid carrier protein (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.
X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.,Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858
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