1d66

<table><tr><td colspan='2'>[[1d66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D66 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d66 OCA], [http://pdbe.org/1d66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d66 RCSB], [http://www.ebi.ac.uk/pdbsum/1d66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d66 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GAL4_YEAST GAL4_YEAST]] This protein is a positive regulator for the gene expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10, and MEL1 which code for the enzymes used to convert galactose to glucose. It recognizes a 17 base pair sequence in (5'-CGGRNNRCYNYNCNCCG-3') the upstream activating sequence (UAS-G) of these genes.

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== Publication Abstract from PubMed ==

A specific DNA complex of the 65-residue, N-terminal fragment of the yeast transcriptional activator, GAL4, has been analysed at 2.7 A resolution by X-ray crystallography. The protein binds as a dimer to a symmetrical 17-base-pair sequence. A small, Zn(2+)-containing domain recognizes a conserved CCG triplet at each end of the site through direct contacts with the major groove. A short coiled-coil dimerization element imposes 2-fold symmetry. A segment of extended polypeptide chain links the metal-binding module to the dimerization element and specifies the length of the site. The relatively open structure of the complex would allow another protein to bind coordinately with GAL4.

DNA recognition by GAL4: structure of a protein-DNA complex.,Marmorstein R, Carey M, Ptashne M, Harrison SC Nature. 1992 Apr 2;356(6368):408-14. PMID:1557122<ref>PMID:1557122</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1d66" style="background-color:#fffaf0;"></div>

*[[DNA-protein interactions|DNA-protein interactions]]

*[[Evans Gal4|Evans Gal4]]

*[[FirstGlance in Jmol|FirstGlance in Jmol]]

*[[Unusual sequence numbering|Unusual sequence numbering]]

*[[User:Eric Martz/Introduction to Structural Bioinformatics 2016|User:Eric Martz/Introduction to Structural Bioinformatics 2016]]

*[[User:Eric Martz/Introduction to Structural Bioinformatics I|User:Eric Martz/Introduction to Structural Bioinformatics I]]

*[[User:Eric Martz/Introduction to Structural Bioinformatics I%2C 2014|User:Eric Martz/Introduction to Structural Bioinformatics I%2C 2014]]

*[[User:Eric Martz/JSmol Notes|User:Eric Martz/JSmol Notes]]

*[[User:Nikhil Malvankar/IW2018|User:Nikhil Malvankar/IW2018]]

*[[User:Wayne Decatur/Biochem642 Molecular Visualization 2010 Fall Sessions|User:Wayne Decatur/Biochem642 Molecular Visualization 2010 Fall Sessions]]

*[[User:Wayne Decatur/Biochem642 Molecular Visualization Sessions|User:Wayne Decatur/Biochem642 Molecular Visualization Sessions]]

*[[User:Wayne Decatur/Gal 4|User:Wayne Decatur/Gal 4]]

*[[User:Wayne Decatur/UNH BCHEM833 Structural Analysis Workshop Session Fall 2012|User:Wayne Decatur/UNH BCHEM833 Structural Analysis Workshop Session Fall 2012]]

== References ==

<references/>

[[Category: Atcc 18824]]

[[Category: Carey, M]]

[[Category: Harrison, S C]]

[[Category: Ptashne, M]]

[[Category: Double helix]]

[[Category: Protein-dna complex]]

[[Category: Transcription-dna complex]]