UvrABC
From Proteopedia
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| - | <StructureSection load='3pih' size=' | + | <StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' > |
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== Function == | == Function == | ||
'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | ||
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== Structural highlights == | == Structural highlights == | ||
UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>. | UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>. | ||
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==3D structures of UvrABC== | ==3D structures of UvrABC== | ||
| - | + | [[UvrABC 3D structures]] | |
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| - | *UvrA | ||
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| - | **[[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br /> | ||
| - | **[[3zqj]] – UvrA – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br /> | ||
| - | **[[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br /> | ||
| - | **[[3ux8]] – GeUvrA - ''Geobacillus''<br /> | ||
| - | **[[2vf7]], [[2vf8]] – DrUvrA2 - ''Deinococcus radiodurans''<br /> | ||
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| - | *UvrB | ||
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| - | **[[1d2m]], [[1c4o]] – UvrB – ''Thermus thermophilus'' <br /> | ||
| - | **[[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br /> | ||
| - | **[[1t5l]] – BcUvrB (mutant) <br /> | ||
| - | **[[1qoj]] – EcUvrB C terminal <br /> | ||
| - | **[[1e52]] – EcUvrB C terminal - NMR<br /> | ||
| - | **[[1d9z]] – BcUvrB + ATP <br /> | ||
| - | **[[2fdc]] – BcUvrB + DNA <br /> | ||
| - | **[[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br /> | ||
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| - | *UvrC | ||
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| - | **[[1kft]], [[1qoj]] – EcUvrC C terminal <br /> | ||
| - | **[[1e52]] – EcUvrC C terminal - NMR<br /> | ||
| - | **[[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br /> | ||
| - | **[[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br /> | ||
| - | **[[1yd2]], [[1yd3]], [[1yd4]], [[1yd5]] – TmUvrC N terminal (mutant)<br /> | ||
| - | **[[1yd6]] – BcUvrC N terminal <br /> | ||
| - | **[[3c65]] – BstUvrC <br /> | ||
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| - | *UvrD or DNA helicase II see [[Helicase]] | ||
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| - | *UvrA-UvrB | ||
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| - | **[[3fpn]] – BstUvrA + UvrB <br /> | ||
| - | **[[3uwx]] – GeUvrA + UvrB <br /> | ||
| - | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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