6p9z

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<StructureSection load='6p9z' size='340' side='right'caption='[[6p9z]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
<StructureSection load='6p9z' size='340' side='right'caption='[[6p9z]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6p9z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P9Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6p9z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P9Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p9z OCA], [http://pdbe.org/6p9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p9z RCSB], [http://www.ebi.ac.uk/pdbsum/6p9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p9z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p9z OCA], [https://pdbe.org/6p9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p9z RCSB], [https://www.ebi.ac.uk/pdbsum/6p9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p9z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6p9z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6p9z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Reeve, S M]]
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[[Category: Staphylococcus aureus]]
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[[Category: Wright, D L]]
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[[Category: Reeve SM]]
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[[Category: Antifolate]]
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[[Category: Wright DL]]
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[[Category: Antimicrobial protein]]
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[[Category: Dhfr]]
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[[Category: Methotrexate]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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Current revision

Staphylococcus aureus Dihydrofolate reductase in complex with NADPH and Methotrexate

PDB ID 6p9z

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