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Malate synthase
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== Function == | == Function == | ||
'''Malate synthase''' (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to [[R/S nomenclature|(S)]]-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. '''MS G''' is formed during growth on glycolate<ref>PMID:12930982</ref> and '''MS A''' which metabolizes glyoxylate formed in the dissimilation of acetate. | '''Malate synthase''' (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to [[R/S nomenclature|(S)]]-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. '''MS G''' is formed during growth on glycolate<ref>PMID:12930982</ref> and '''MS A''' which metabolizes glyoxylate formed in the dissimilation of acetate. | ||
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| + | See also: [[Glyoxylate cycle]] | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3d structures of malate synthase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''Malate synthase''' | ||
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| - | **[[1y8b]], [[2jqx]] – EcMS G (mutant) – ''Escherichia coli'' - NMR<br /> | ||
| - | **[[3cuz]], [[3cv1]] – EcMS A<br /> | ||
| - | **[[4ex4]] – MS G + Mg – ''Mycobacterium leprae''<br /> | ||
| - | **[[5h8p]] – MtMS G – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[5h8m]] – MtMS G (mutant) + Mg <br /> | ||
| - | **[[3cux]] – MS + Mg – ''Bacillus anthracis''<br /> | ||
| - | **[[5oas]] – PaMS G + Mg – ''Pseudomonas aeruginosa''<br /> | ||
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| - | *Malate synthase binary complex | ||
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| - | **[[1d8c]] – EcMS G (mutant) + glyoxylate + Mg <br /> | ||
| - | **[[3cv2]] – EcMS A + oxalate + Mg <br /> | ||
| - | **[[1n8i]] – MtMS G + glyoxylate + Mg <br /> | ||
| - | **[[5h8u]] – MtMS G + malate + Mg <br /> | ||
| - | **[[6axe]] – MtMS G + acetyl CoA + Mg <br /> | ||
| - | **[[5c7v]], [[5cah]], [[5cjm]], [[5e9x]] – MtMS G (mutant) + pyrrole derivative + Mg <br /> | ||
| - | **[[5cew]] – MtMS G (mutant) + pyridine derivative + Mg <br /> | ||
| - | **[[5cjn]] – MtMS G (mutant) + quinoxaline derivative + Mg <br /> | ||
| - | **[[5dx7]] – MtMS G (mutant) + isoxazole derivative + Mg <br /> | ||
| - | **[[5c9r]], [[5c9u]], [[5c9w]], [[5cbj]], [[5ccz]] – MtMS G (mutant) + phenyl derivative + Mg <br /> | ||
| - | **[[5c9x]], [[5cbi]] – MtMS G (mutant) + benzoate derivative + Mg <br /> | ||
| - | **[[5cak]], [[5cbb]], [[5cc3]], [[5cc5]], [[5cc6]], [[5cc7]], [[5drc]], [[5dri]], [[5ecv]] – MtMS G (mutant) + indole derivative + Mg <br /> | ||
| - | **[[5t8g]] – MtMS G (mutant) + thiophene derivative + Mg <br /> | ||
| - | **[[6dnp]], [[6dlj]], [[6dko]], [[6c8p]], [[6c7b]], [[6c6o]], [[6c2x]], [[6ba7]], [[6axb]], [[6au9]] – MtMS G + diketoacid inhibitor + Mg <br /> | ||
| - | **[[6dl9]], [[6bu1]], [[6asu]], [[6as6]], [[6apz]] – MtMS G (mutant) + phenyldiketoacid inhibitor + Mg <br /> | ||
| - | **[[3s9i]], [[3s9z]], [[3sad]], [[3saz]], [[3sb0]] – MtMS G (mutant) + inhibitor + Mg <br /> | ||
| - | **[[3oyx]], [[3pug]] – HvMS G + glyoxylate + Mg – ''Haloferax volcanii''<br /> | ||
| - | **[[5tao]] – HvMS G + glyoxylate + Pb<br /> | ||
| - | **[[5vfb]] – PaMS + glycolate + Ni<br /> | ||
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| - | *Malate synthase ternary complex | ||
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| - | **[[1p7t]] – EcMS G (mutant) + pyruvate + Mg + acetyl-CoA<br /> | ||
| - | **[[3oyz]] – HvMS + pyruvate + Mg + acetyl-CoA<br /> | ||
| - | **[[1n8w]] – MtMS G + glyoxylate + Mg + CoA<br /> | ||
| - | **[[2gq3]] – MtMS G + malate + Mg + CoA<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Anstrom DM, Kallio K, Remington SJ. Structure of the Escherichia coli malate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 A resolution. Protein Sci. 2003 Sep;12(9):1822-32. PMID:12930982
- ↑ Anstrom DM, Remington SJ. The product complex of M. tuberculosis malate synthase revisited. Protein Sci. 2006 Aug;15(8):2002-7. PMID:16877713 doi:15/8/2002
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