Mannosidase

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Rice β-mannosidase complex with β-mannose, glycerol and HEPES (PDB entry 4jie)

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References

↑ Heikinheimo P, Helland R, Leiros HK, Leiros I, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S, Hough E. The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation. J Mol Biol. 2003 Mar 28;327(3):631-44. PMID:12634058
↑ Ademark P, Lundqvist J, Hagglund P, Tenkanen M, Torto N, Tjerneld F, Stalbrand H. Hydrolytic properties of a beta-mannosidase purified from Aspergillus niger. J Biotechnol. 1999 Oct 8;75(2-3):281-9. PMID:10553664
↑ Sobala LF, Fernandes PZ, Hakki Z, Thompson AJ, Howe JD, Hill M, Zitzmann N, Davies S, Stamataki Z, Butters TD, Alonzi DS, Williams SJ, Davies GJ. Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc Natl Acad Sci U S A. 2020 Nov 5. pii: 2013620117. doi:, 10.1073/pnas.2013620117. PMID:33154157 doi:http://dx.doi.org/10.1073/pnas.2013620117
↑ Berg T, Riise HM, Hansen GM, Malm D, Tranebjaerg L, Tollersrud OK, Nilssen O. Spectrum of mutations in alpha-mannosidosis. Am J Hum Genet. 1999 Jan;64(1):77-88. PMID:9915946 doi:http://dx.doi.org/S0002-9297(07)61660-7
↑ Uchino Y, Fukushige T, Yotsumoto S, Hashiguchi T, Taguchi H, Suzuki N, Konohana I, Kanzaki T. Morphological and biochemical studies of human beta-mannosidosis: identification of a novel beta-mannosidase gene mutation. Br J Dermatol. 2003 Jul;149(1):23-9. PMID:12890191
↑ Tankrathok A, Iglesias-Fernandez J, Luang S, Robinson RC, Kimura A, Rovira C, Hrmova M, Ketudat Cairns JR. Structural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 beta-D-mannosidase. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2124-35. doi:, 10.1107/S0907444913020568. Epub 2013 Sep 20. PMID:24100330 doi:http://dx.doi.org/10.1107/S0907444913020568

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Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Mannosidase"

Category: Topic Page

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 == Function ==
-'''Mannosidase''' (MAN) is an enzyme which hydrolyzes mannose.  There are 2 kinds of MAN.  '''α-MAN''' which hydrolyzes α-mannose<ref>PMID:12634058</ref> and '''β-MAN''' which hydrolyzes β-1,4-linked manno-oligosaccharides<ref>PMID:10553664</ref>.  α-MAN isozymes are classified as class I and II.  '''Mannan endo-1,4-β-MAN''' hydrolyzes 1-4-β-D-mannosidic linkages in mannans, galactomannans and glucomannans.  See some details in [[Molecular Playground/ERMan1]].
+'''Mannosidase''' (MAN) is an enzyme which hydrolyzes mannose.  There are 2 kinds of MAN.  '''α-MAN''' which hydrolyzes α-mannose<ref>PMID:12634058</ref> and '''β-MAN''' which hydrolyzes β-1,4-linked manno-oligosaccharides<ref>PMID:10553664</ref>.  α-MAN isozymes are classified as class I and II.
+* '''Mannan endo-1,4-β-MAN''' hydrolyzes 1-4-β-D-mannosidic linkages in mannans, galactomannans and glucomannans.
+* '''Endo-1,2-α-MAN''' is the Endo-acting glycoside hydrolase involved in N-glycan trimming located in the Golgi<ref>PMID:33154157</ref>
+See some details in [[Molecular Playground/ERMan1]]. See also [[Carbohydrate Metabolism]].
 == Disease ==
@@ Line 15: / Line 18: @@
 </StructureSection>
-==3D structures of mannosidase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*α-MAN
-**[[1o7d]] - αMAN – bovine<br />
-**[[6b9o]] - jbMAN – jack bean<br />
-**[[2wvy]], [[2ww2]], [[4acy]], [[4acz]], [[4ad0]], [[4c1s]] - αMAN - ''Bacterioides thetaiotaomicron''<br />
-**[[1hcu]] - TrαMAN – ''Trichoderma reesei''<br />
-*α-MAN class I
-**[[1fmi]] - hαMAN I - human<br />
-**[[1fo2]] - hαMAN I + deoxymannojirimycin<br />
-**[[1fo3]] - hαMAN I+ kifunensine<br />
-**[[1x9d]] - hαMAN I residues 243-699 + polysaccharide analog<br />
-**[[1nxc]] - mαMAN I + mannose – mouse<br />
-**[[6b9p]] - jbMAN + inhibitor<br />
-**[[5jm0]] - yαMAN I – yeast<br />
-**[[1dl2]] - yαMAN I catalytic domain + mannose <br />
-**[[1g6i]] - yαMAN I + deoxymannojirimycin<br />
-**[[2ri8]] - PcαMAN I + glycerol – ''Penicillium citrinum''<br />
-**[[1kre]], [[1kkt]] - PcαMAN I + mannose<br />
-**[[2ri9]] - PcαMAN I + substrate analog<br />
-**[[1krf]] - PcαMAN I + kifunensine + mannose<br />
-*α-MAN class II
-**[[2wyh]] - SpαMAN II – ''Streptococcus pyrogenes''<br />
-**[[3bub]], [[1hty]] - DmαMAN II catalytic domain – ''Drosophila melanogaster''<br />
-**[[3bud]] - DmαMAN II catalytic domain (mutant) <br />
-**[[3bui]] - DmαMAN II catalytic domain (mutant) + Tris<br />
-**[[3bup]], [[3buq]], [[3czs]] - DmαMAN II catalytic domain (mutant) + mannose<br />
-**[[3bvt]], [[3bvu]], [[3bvv]], [[3bvw]], [[3bvx]] - DmαMAN II catalytic domain (mutant) + mannopyranoside<br />
-**[[1r33]], [[1r34]] - DmαMAN II catalytic domain + mannopyranoside<br />
-**[[3ddf]], [[3ddg]], [[2f18]], [[2f1a]], [[2f1b]] - DmαMAN II catalytic domain + pyrrolidin<br />
-**[[2alw]] - DmαMAN II catalytic domain + noeuromycin<br />
-**[[3cv5]] - DmαMAN II catalytic domain + polysaccharide<br />
-**[[3czn]] - DmαMAN II catalytic domain (mutant) + polysaccharide<br />
-**[[2wyi]] - SpαMAN II + swainsonine<br />
-**[[3blb]], [[1hww]] - DmαMAN II + swainsonine<br />
-**[[3ejp]], [[3ejq]], [[3ejr]], [[3ejs]], [[3ejt]], [[3eju]], [[2ow6]], [[2ow7]] - DmαMAN II catalytic domain + swainsonine analog<br />
-**[[3dx0]], [[3dx2]], [[2f7o]] - DmαMAN II catalytic domain + mannostatine<br />
-**[[3dx1]], [[3dx3]], [[3dx4]], [[2f7p]] - DmαMAN II catalytic domain + mannostatine analog<br />
-**[[3d4y]], [[3d4z]] - DmαMAN II catalytic domain + imidazole derivative<br />
-**[[3d50]], [[3d51]], [[3d52]] - DmαMAN II catalytic domain + inhibitor<br />
-**[[2fyv]], [[2f7q]], [[2f7r]] - DmαMAN II catalytic domain + amino-salacinol carboxylate analog<br />
-**[[1tqv]], [[1tqw]], [[1tqs]], [[1tqt]], [[1tqu]] - DmαMAN II catalytic domain (mutant) + seleno-salacinol<br />
-**[[1ps3]] - DmαMAN II catalytic domain + kifunensine<br />
-**[[1qwn]] - DmαMAN II catalytic domain + intermediate<br />
-**[[1hxk]] - DmαMAN II catalytic domain + deoxymannojirimycin<br />
-**[[1qwu]] - DmαMAN II catalytic domain (mutant) + guloside<br />
-**[[1qx1]] - DmαMAN II catalytic domain (mutant) + mannosyl
-*α-1,2-MAN
-**[[4ayo]] – CaαMAN - ''Caulobacter''<br />
-**[[4ayp]], [[4ayq]], [[5meh]] – CaαMAN + mannose derivative<br />
-**[[4ayr]] – CaαMAN + noeuromycin<br />
-**[[5ne5]] – CaαMAN + kifunensine<br />
-**[[5kkb]] – mαMAN + mannose derivative<br />
-**[[5kij]] – hαMAN + mannose derivative<br />
-**[[5kk7]] – hαMAN (mutant) + disaccharide derivative<br />
-*β-MAN
-**[[6dtt]] - mMAN <br />
-**[[6ddu]] - mMAN + β-mannose <br />
-**[[2je8]] - BtβMAN residues 26-864 <br />
-**[[2wbk]] - BtβMAN residues 26-864 + mannopyranoside <br />
-**[[2vqt]], [[2vr4]], [[2vjx]], [[2vl4]], [[2vmf]], [[2vo5]], [[2vot]], [[2vqu]] - BtβMAN residues 26-864 + piperidine derivative<br />
-**[[1oh4]], [[1of4]] - TmβMAN catalytic domain + mannose – ''Thermotoga maritima''<br />
-**[[1of3]] - TmβMAN catalytic domain<br />
-**[[1uz4]] - CmβMAN + inhibitor – ''Cellvibrio mixtus''<br />
-**[[1uuq]] - CmβMAN<br />
-**[[2whk]] - βMAN – ''Bacillus subtilis''<br />
-**[[4jho]] - rβMAN – rice<br />
-**[[4jie]] - rβMAN + β-mannose<br />
-**[[4cvu]], [[4uoj]] – βMAN - ''Trichoderma harzianum''<br />
-**[[5n6u]] - βMAN + β-mannose – ''Dictyoglomus thermophilum''<br />
-**[[6byc]] - XaMAN – ''Xanthomonas axonopodis''<br />
-**[[6byg]], [[6byi]] - XaMAN (mutant)<br />
-**[[6bye]] - XaMAN + β-mannose<br />
-**[[4zxo]] - MAN – ''Bacterioides ovatus''<br />
-**[[2whj]] - BaMAN – ''Bacillus agaradhaerens''<br />
-**[[2whl]] - BaMAN + β-mannose <br />
-*Mannan endo-1,4-β-MAN
-**[[1gvy]], [[1odz]], [[1gw1]], [[2whm]] - PcβMAN (mutant) + mannose derivative – ''Pseudomonas cellulosa''<br />
-**[[1j9y]], [[1r7o]] - PcβMAN<br />
-**[[2c0h]] - βMAN (mutant) – blue mussel<br />
-**[[2whk]], [[4yn5]], [[3jug]], [[2qha]] - βMAN – ''Bacillus subtilis''<br />
-**[[1rh9]] – βMAN – ''Solanum lycopersicum''<br />
-**[[3pz9]], [[3pzg]] – TpβMAN – ''Thermotoga petrophila''<br />
-**[[3pzi]] – TpβMAN + glucose<br />
-**[[3pzm]], [[3pzn]] – TpβMAN + glycerol<br />
-**[[3pzo]], [[3pzq]] – TpβMAN + maltose<br />
-**[[3ziz]] - βMAN – ''Podspora anserina''<br />
-**[[3wh9]] - βMAN – ''Aspergillus niger''<br />
-**[[1qns]], [[1qnr]], [[1qnq]], [[1qnp]], [[1qno]] - TrMAN <br />
-*Endo-α-MAN
-**[[4utf]] - BxαMAN – ''Bacterioides xylanisolvens''<br />
-**[[4ad5]], [[4ad4]], [[4ad3]], [[4ad2]], [[4ad1]] – BxαMAN + mannose derivative<br />
-*Exo-β-1,4-MAN
-**[[4lyp]] - RmβMAN – ''Rhizomucor miehei''<br />
-**[[4lyq]], [[4lyr]] - RmβMAN (mutant)<br />
-**[[4nrr]] - RmβMAN (mutant) + mannosyl-fructose<br />
-**[[4nrs]] - RmβMAN (mutant) + mannobiose<br />
-**[[6gvb]] - βMAN – ''Cutibacterium acnes''<br />
-*Exo-α-1,6-MAN
-**[[5m7i]] - CpαMAN (mutant) + mannobiose – ''Clostridium perfringenes''<br />
-**[[5m7y]] - CpαMAN (mutant) + mannotriose <br />
-**[[6rqk]] - CpMAN + mannoimidazole<br />
-*β-MAN/β-glucosidase
-**[[4re2]], [[4re3]], [[4re4]] - rβMAN/βGLU <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

Mannosidase

From Proteopedia

Current revision

Contents

Function

Disease

Structural highlights

3D structures of mannosidase

References

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