6l53

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6l53 is ON HOLD Authors: Xu, Y., Qi, Y. Description: Structure of SMG1 Category: Unreleased Structures Category: Qi, Y Category: Xu, Y)
Current revision (10:45, 27 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6l53 is ON HOLD
+
==Structure of SMG1==
 +
<StructureSection load='6l53' size='340' side='right'caption='[[6l53]], [[Resolution|resolution]] 3.63&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6l53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L53 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.63&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l53 OCA], [https://pdbe.org/6l53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l53 RCSB], [https://www.ebi.ac.uk/pdbsum/6l53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l53 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SMG1_HUMAN SMG1_HUMAN] Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.<ref>PMID:11331269</ref> <ref>PMID:11544179</ref> <ref>PMID:15175154</ref> <ref>PMID:16452507</ref>
-
Authors: Xu, Y., Qi, Y.
+
==See Also==
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
Description: Structure of SMG1
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Qi, Y]]
+
__TOC__
-
[[Category: Xu, Y]]
+
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Qi Y]]
 +
[[Category: Xu Y]]

Current revision

Structure of SMG1

PDB ID 6l53

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6l53"
Personal tools