6sg2
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==FeFe Hydrogenase from Desulfovibrio desulfuricans in Hinact state== | |
| + | <StructureSection load='6sg2' size='340' side='right'caption='[[6sg2]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6sg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SG2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFH:dicarbonyl[bis(cyanide-kappaC)]-mu-(iminodimethanethiolatato-1kappaS 2kappaS)-mu-(oxomethylidene)diiron(2+)+sulphide'>LFH</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sg2 OCA], [https://pdbe.org/6sg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sg2 RCSB], [https://www.ebi.ac.uk/pdbsum/6sg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sg2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A4Y3TCU2_DESDE A0A4Y3TCU2_DESDE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [FeFe] hydrogenases are the most active H 2 converting catalysts in nature but their extreme oxygen sensitivity limits their use in technological applications. The [FeFe] hydrogenases from sulfate reducing bacteria can be purified in an O 2 -stable state called H inact . To date, the structure and mechanism of formation of H inact remain unknown. Our 1.65 A crystal structure of this state reveals a sulfur ligand bound to the open coordination site. Furthermore, in-depth spectroscopic characterization by X-ray absorption spectroscopy (XAS), nuclear resonance vibrational spectroscopy (NRVS), resonance Raman (RR) spectroscopy and infrared (IR) spectroscopy, together with hybrid quantum mechanical and molecular mechanical (QM/MM) calculations, provide detailed chemical insight into the H inact state and its mechanism of formation. This may facilitate the design of O 2 -stable hydrogenases and molecular catalysts. | ||
| - | + | Caught in the Hinact: Crystal Structure and Spectroscopy Reveal a Sulfur Bound to the Active Site of an O2-stable State of [FeFe] Hydrogenase.,Rodriguez-Macia P, Galle L, Bjornsson R, Lorent C, Zebger I, Yoda Y, Cramer S, DeBeer S, Span I, Birrell J Angew Chem Int Ed Engl. 2020 Jun 2. doi: 10.1002/anie.202005208. PMID:32488975<ref>PMID:32488975</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6sg2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Desulfovibrio desulfuricans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Galle LM]] | ||
| + | [[Category: Span I]] | ||
Current revision
FeFe Hydrogenase from Desulfovibrio desulfuricans in Hinact state
| |||||||||||
