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6ub9
From Proteopedia
(Difference between revisions)
(New page: ==Crystal structure of tryptophan synthase from M. tuberculosis - AMINOACRYLATE- AND BRD6309-BOUND FORM== <StructureSection load='6ub9' size='340' side='right'caption='6ub9, [[Resolut...) |
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<StructureSection load='6ub9' size='340' side='right'caption='[[6ub9]], [[Resolution|resolution]] 2.78Å' scene=''> | <StructureSection load='6ub9' size='340' side='right'caption='[[6ub9]], [[Resolution|resolution]] 2.78Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6ub9]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6ub9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6dua 6dua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UB9 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=H9V:(2R,3S,4R)-3-(4-chloro-2,6-difluoro[1,1-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile'>H9V</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=P1T:2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC+ACID'>P1T</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.783Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=H9V:(2R,3S,4R)-3-(4-chloro-2,6-difluoro[1,1-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile'>H9V</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=P1T:2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC+ACID'>P1T</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ub9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ub9 OCA], [https://pdbe.org/6ub9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ub9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ub9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ub9 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. |
| + | |||
| + | ==See Also== | ||
| + | *[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | + | [[Category: Chang C]] | |
| - | + | [[Category: Jedrzejczak R]] | |
| - | [[Category: Chang | + | [[Category: Joachimiak A]] |
| - | [[Category: Jedrzejczak | + | [[Category: Maltseva NI]] |
| - | [[Category: Joachimiak | + | [[Category: McCarren P]] |
| - | [[Category: Maltseva | + | [[Category: Michalska K]] |
| - | [[Category: McCarren | + | [[Category: Nag PP]] |
| - | [[Category: Michalska | + | [[Category: Satchell K]] |
| - | [[Category: Nag | + | |
| - | [[Category: Satchell | + | |
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Current revision
Crystal structure of tryptophan synthase from M. tuberculosis - AMINOACRYLATE- AND BRD6309-BOUND FORM
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