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6iko

From Proteopedia

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Crystal structure of mouse GAS7cb

Structural highlights

6iko is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.756Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GAS7_MOUSE May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

Publication Abstract from PubMed

Phagocytosis is a cellular process for internalization of micron-sized large particles including pathogens. The Bin-Amphiphysin-Rvs167 (BAR) domain proteins, including the FCH-BAR (F-BAR) domain proteins, impose specific morphologies on lipid membranes. Most BAR domain proteins are thought to form membrane invaginations or protrusions by assembling into helical submicron-diameter filaments, such as on clathrin-coated pits, caveolae, and filopodia. However, the mechanism by which BAR domain proteins assemble into micron-scale phagocytic cups was unclear. Here, we show that the two-dimensional sheet-like assembly of Growth Arrest-Specific 7 (GAS7) plays a critical role in phagocytic cup formation in macrophages. GAS7 has the F-BAR domain that possesses unique hydrophilic loops for two-dimensional sheet formation on flat membranes. Super-resolution microscopy reveals the similar assemblies of GAS7 on phagocytic cups and liposomes. The mutations of the loops abolishes both the membrane localization of GAS7 and phagocytosis. Thus, the sheet-like assembly of GAS7 plays a significant role in phagocytosis.

Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.,Hanawa-Suetsugu K, Itoh Y, Ab Fatah M, Nishimura T, Takemura K, Takeshita K, Kubota S, Miyazaki N, Wan Mohamad Noor WNI, Inaba T, Nguyen NTH, Hamada-Nakahara S, Oono-Yakura K, Tachikawa M, Iwasaki K, Kohda D, Yamamoto M, Kitao A, Shimada A, Suetsugu S Nat Commun. 2019 Oct 18;10(1):4763. doi: 10.1038/s41467-019-12738-w. PMID:31628328^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hanawa-Suetsugu K, Itoh Y, Ab Fatah M, Nishimura T, Takemura K, Takeshita K, Kubota S, Miyazaki N, Wan Mohamad Noor WNI, Inaba T, Nguyen NTH, Hamada-Nakahara S, Oono-Yakura K, Tachikawa M, Iwasaki K, Kohda D, Yamamoto M, Kitao A, Shimada A, Suetsugu S. Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7. Nat Commun. 2019 Oct 18;10(1):4763. doi: 10.1038/s41467-019-12738-w. PMID:31628328 doi:http://dx.doi.org/10.1038/s41467-019-12738-w

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6iko"

@@ Line 3: / Line 3: @@
 <StructureSection load='6iko' size='340' side='right'caption='[[6iko]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6iko]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IKO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6iko]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IKO FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iko OCA], [http://pdbe.org/6iko PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iko RCSB], [http://www.ebi.ac.uk/pdbsum/6iko PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iko ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.756&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iko OCA], [https://pdbe.org/6iko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iko RCSB], [https://www.ebi.ac.uk/pdbsum/6iko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iko ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/GAS7_MOUSE GAS7_MOUSE] May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Hanawa-Suetsugu, K]]
+[[Category: Hanawa-Suetsugu K]]
-[[Category: Itoh, Y]]
+[[Category: Itoh Y]]
-[[Category: Kohda, D]]
+[[Category: Kohda D]]
-[[Category: Shimada, A]]
+[[Category: Shimada A]]
-[[Category: Suetsugu, S]]
+[[Category: Suetsugu S]]
-[[Category: F-bar domain]]
-[[Category: Lipid binding protein]]
-[[Category: Phagocytosis]]

6iko

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Current revision

Crystal structure of mouse GAS7cb

Structural highlights

Function

Publication Abstract from PubMed

References

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