1hkf

From Proteopedia

(Difference between revisions)

Current revision

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

Structural highlights

1hkf is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NCTR2_HUMAN Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.,Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D Structure. 2003 Jun;11(6):725-34. PMID:12791260^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J Exp Med. 1999 Mar 1;189(5):787-96. PMID:10049942 doi:10.1084/jem.189.5.787
↑ Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D. The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. Structure. 2003 Jun;11(6):725-34. PMID:12791260

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hkf"

@@ Line 3: / Line 3: @@
 <StructureSection load='1hkf' size='340' side='right'caption='[[1hkf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [http://pdbe.org/1hkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [http://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [https://pdbe.org/1hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [https://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NCTR2_HUMAN NCTR2_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:10049942</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 11: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkf_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 32: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Biassoni, R]]
+[[Category: Biassoni R]]
-[[Category: Bolognesi, M]]
+[[Category: Bolognesi M]]
-[[Category: Bordo, D]]
+[[Category: Bordo D]]
-[[Category: Cantoni, C]]
+[[Category: Cantoni C]]
-[[Category: Conte, R]]
+[[Category: Conte R]]
-[[Category: Moretta, A]]
+[[Category: Moretta A]]
-[[Category: Moretta, L]]
+[[Category: Moretta L]]
-[[Category: Ponassi, M]]
+[[Category: Ponassi M]]
-[[Category: Spallarossa, A]]
+[[Category: Spallarossa A]]
-[[Category: Immunoglobulin domain]]
-[[Category: Natural cytotoxicity receptor]]
-[[Category: Nkp44]]
-[[Category: Receptor]]

1hkf

From Proteopedia

Current revision

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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