Methylesterase
From Proteopedia
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<StructureSection load='3c5w' size='350' side='right' caption='Human protein phosphatase methylesterase (green) complex with protein phosphatase 2A subunit A (cyan) and subunit C (magenta) (PDB entry [[3c5w]])' scene='48/489289/Cv/1'> | <StructureSection load='3c5w' size='350' side='right' caption='Human protein phosphatase methylesterase (green) complex with protein phosphatase 2A subunit A (cyan) and subunit C (magenta) (PDB entry [[3c5w]])' scene='48/489289/Cv/1'> | ||
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== Function == | == Function == | ||
'''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. <br /> | '''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. <br /> | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of methylesterase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Pectin methylesterase | ||
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| - | **[[1qjv]] – EcME – ''Erwinia chrysanthemi''<br /> | ||
| - | **[[1gq8]] – ME – carrot<br /> | ||
| - | **[[3uw0]] – ME – ''Yersinia enterocolitica''<br /> | ||
| - | **[[1xg2]] – ME + protein inhibitor – ''Solanum lycopersicum''<br /> | ||
| - | **[[2nsp]], [[2nst]], [[2nt6]], [[2nt9]] – EcME (mutant) + hexasaccharide<br /> | ||
| - | **[[2ntp]], [[2ntb]], [[2ntq]] – EcME + hexasaccharide | ||
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| - | *Aclacinomycin methylesterase | ||
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| - | **[[1q0r]], [[1q0z]] – ME + product analog – ''Streptomyces purpurascens'' | ||
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| - | *Protein phosphatase methylesterase | ||
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| - | **[[3c5v]] – hME1 – human<br /> | ||
| - | **[[3c5w]] – hME1 + protein phosphatase 2A | ||
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| - | *4-o-methyl-glucuronoyl methylesterase | ||
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| - | **[[4g4g]] – MtME – ''Myceliophthora thermophila''<br /> | ||
| - | **[[4g4i]] – MtME (mutant)<br /> | ||
| - | **[[4g4j]] – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate<br /> | ||
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| - | *Methylesterase 5 or a-hydroxynitrile lyase | ||
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| - | **[[6cob]], [[6cof]] – AtME5 (mutant) – ''Arabidopsis thaliana''<br /> | ||
| - | **[[6coc]], [[6cod]], [[6cog]] – AtME5 (mutant) + benzaldehyde<br /> | ||
| - | **[[6coe]], [[6coh]] – AtME5 (mutant) + benzaldehyde + mandelic acid nitrile<br /> | ||
| - | **[[6coi]] – AtME5 (mutant) + benzaldehyde + mandelic acid nitrile + CN<br /> | ||
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| - | *CheB methylesterase see [[Chemotaxis protein]] | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Simms SA, Keane MG, Stock J. Multiple forms of the CheB methylesterase in bacterial chemosensing. J Biol Chem. 1985 Aug 25;260(18):10161-8. PMID:2991277
- ↑ Micheli F. Pectin methylesterases: cell wall enzymes with important roles in plant physiology. Trends Plant Sci. 2001 Sep;6(9):414-9. PMID:11544130
- ↑ Wang Y, Niemi J, Mantsala P. Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products. FEMS Microbiol Lett. 2002 Feb 19;208(1):117-22. PMID:11934504
- ↑ Wandzioch E, Pusey M, Werda A, Bail S, Bhaskar A, Nestor M, Yang JJ, Rice LM. PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells. Cancer Res. 2014 Aug 15;74(16):4295-305. doi: 10.1158/0008-5472.CAN-13-3130. Epub, 2014 Jun 13. PMID:24928782 doi:http://dx.doi.org/10.1158/0008-5472.CAN-13-3130
- ↑ Spanikova S, Biely P. Glucuronoyl esterase--novel carbohydrate esterase produced by Schizophyllum commune. FEBS Lett. 2006 Aug 21;580(19):4597-601. Epub 2006 Jul 21. PMID:16876163 doi:http://dx.doi.org/10.1016/j.febslet.2006.07.033
- ↑ Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell. 2008 Apr 4;133(1):154-63. PMID:18394995 doi:http://dx.doi.org/10.1016/j.cell.2008.02.041
