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| | ==The solution structure of molt-inhibiting hormone from the kuruma prawn== | | ==The solution structure of molt-inhibiting hormone from the kuruma prawn== |
| - | <StructureSection load='1j0t' size='340' side='right'caption='[[1j0t]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='1j0t' size='340' side='right'caption='[[1j0t]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1j0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Kuruma_prawn Kuruma prawn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J0T FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1j0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_japonicus Penaeus japonicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J0T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0t OCA], [http://pdbe.org/1j0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j0t RCSB], [http://www.ebi.ac.uk/pdbsum/1j0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j0t ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0t OCA], [https://pdbe.org/1j0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j0t RCSB], [https://www.ebi.ac.uk/pdbsum/1j0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j0t ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/MIH_PENJP MIH_PENJP]] Inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops. Has little or no hyperglycemic activity. | + | [https://www.uniprot.org/uniprot/MIH_PENJP MIH_PENJP] Inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops. Has little or no hyperglycemic activity. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Kuruma prawn]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Katayama, H]] | + | [[Category: Penaeus japonicus]] |
| - | [[Category: Nagasawa, H]] | + | [[Category: Katayama H]] |
| - | [[Category: Nagata, K]] | + | [[Category: Nagasawa H]] |
| - | [[Category: Ohira, T]] | + | [[Category: Nagata K]] |
| - | [[Category: Tanokura, M]] | + | [[Category: Ohira T]] |
| - | [[Category: Yumoto, F]] | + | [[Category: Tanokura M]] |
| - | [[Category: Alpha-helical protein]]
| + | [[Category: Yumoto F]] |
| - | [[Category: Hormone-growth factor complex]]
| + | |
| Structural highlights
Function
MIH_PENJP Inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops. Has little or no hyperglycemic activity.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Molting in crustaceans is controlled by molt-inhibiting hormone (MIH) and ecdysteroids. It is presumed that MIH inhibits the synthesis and the secretion of ecdysteroids by the Y-organ, resulting in molt suppression. The amino acid sequence of MIH is similar to that of crustacean hyperglycemic hormone (CHH), and therefore, they form a peptide family referred to as the CHH family. Most of the CHH family peptides show no cross-activity, whereas a few peptides show multiple hormonal activities. To reveal the structural basis of this functional specificity, we determined the solution structure of MIH from the Kuruma prawn Marsupenaeus japonicus and compared the solution structure of MIH with a homology-modeled structure of M. japonicus CHH. The solution structure of MIH consisted of five alpha-helices and no beta-structures, constituting a novel structural motif. The homology-modeled structure of M. japonicus CHH was very similar to the solution structure of MIH with the exception of the absence of the N-terminal alpha-helix and the C-terminal tail, which were sterically close to each other. The surface properties of MIH around this region were quite different from those of CHH. These results strongly suggest that this region is a functionally important site for conferring molt-inhibiting activity.
The solution structure of molt-inhibiting hormone from the Kuruma prawn Marsupenaeus japonicus.,Katayama H, Nagata K, Ohira T, Yumoto F, Tanokura M, Nagasawa H J Biol Chem. 2003 Mar 14;278(11):9620-3. Epub 2003 Jan 7. PMID:12519766[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Katayama H, Nagata K, Ohira T, Yumoto F, Tanokura M, Nagasawa H. The solution structure of molt-inhibiting hormone from the Kuruma prawn Marsupenaeus japonicus. J Biol Chem. 2003 Mar 14;278(11):9620-3. Epub 2003 Jan 7. PMID:12519766 doi:10.1074/jbc.M212962200
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