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Myosin 3D Structures

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(New page: == 3D Structures of Myosin == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| * Myosin I **4byf – hMIC + ca...)
Current revision (09:49, 10 July 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 13: Line 13:
**[[4a7f]] - DdMI HC + rActin + rTropomyosin – Cryo EM<br />
**[[4a7f]] - DdMI HC + rActin + rTropomyosin – Cryo EM<br />
**[[4a7h]], [[4a7l]] - DdMI HC (mutant) + rActin + rTropomyosin – Cryo EM<br />
**[[4a7h]], [[4a7l]] - DdMI HC (mutant) + rActin + rTropomyosin – Cryo EM<br />
 +
**[[6ui4]] – MI + calmodulin – fungus<br />
**[[5ibw]] – DdMIC HC + Ca-binding protein <br />
**[[5ibw]] – DdMIC HC + Ca-binding protein <br />
**[[2drk]], [[2drm]] – MI HC + 10-mer peptide – ''Acanthamoeba castellanii''<br />
**[[2drk]], [[2drm]] – MI HC + 10-mer peptide – ''Acanthamoeba castellanii''<br />
Line 29: Line 30:
* Myosin II
* Myosin II
 +
**[[8efd]], [[8efe]] - hMII HC+LC – Cryo EM<br />
 +
**[[8efh]], [[8efi]] - hMII HC + actin + tropomyocin – Cryo EM<br />
 +
**[[2fxm]], [[2fxo]] – hMII HC S2 fragment <br />
 +
**[[2lnk]] – hMII HC + protein S100-A4 – NMR<br />
 +
**[[3zwh]] - hMII HC + protein S100-A4 (mutant)<br />
**[[1o1g]], [[1o1a]] , [[1o1b]], [[1o1c]], [[1o1d]], [[1o1e]], [[1o1f]], [[1o18]], [[1o19]], [[1mvw]], [[1m8q]] – cMII RLC+ELC+HC+actin – tomography - chicken<br />
**[[1o1g]], [[1o1a]] , [[1o1b]], [[1o1c]], [[1o1d]], [[1o1e]], [[1o1f]], [[1o18]], [[1o19]], [[1mvw]], [[1m8q]] – cMII RLC+ELC+HC+actin – tomography - chicken<br />
 +
**[[7mf3]] - cMII HC+LC + MI light polypeptide 6 – Cryo EM<br />
**[[3lla]] – cMII HC α-kinase domain+AMPPCP<br />
**[[3lla]] – cMII HC α-kinase domain+AMPPCP<br />
**[[3lmh]] – cMII HC α-kinase domain+ADP<br />
**[[3lmh]] – cMII HC α-kinase domain+ADP<br />
**[[3lmi]] – cMII HC α-kinase domain (mutant) +ATP<br />
**[[3lmi]] – cMII HC α-kinase domain (mutant) +ATP<br />
-
**[[2fxm]], [[2fxo]] – hMII HC S2 fragment <br />
+
**[[6xe9]], [[6z47]] - MII HC 11 + LC 9 – turkey - Cryo EM<br />
-
**[[2lnk]] – hMII HC + protein S100-A4 – NMR<br />
+
-
**[[3zwh]] - hMII HC + protein S100-A4 (mutant)<br />
+
**[[3i5f]] – LpMII RLC+HC+ADP+Mg – ''Loligo pealei''<br />
**[[3i5f]] – LpMII RLC+HC+ADP+Mg – ''Loligo pealei''<br />
**[[3i5g]], [[3i5h]] – LpMII RLC+HC+ELC<br />
**[[3i5g]], [[3i5h]] – LpMII RLC+HC+ELC<br />
Line 46: Line 51:
**[[3mnq]] - DdMII HC MD + ADP-VO4 + reservatrol<br />
**[[3mnq]] - DdMII HC MD + ADP-VO4 + reservatrol<br />
**[[4pjk]] - DdMII HC MD + ADP<br />
**[[4pjk]] - DdMII HC MD + ADP<br />
-
**[[3bas]], [[3bat]], [[1fmv]] - DdMII HC<br />
+
**[[3bas]], [[3bat]], [[1fmv]], [[6z7t]] - DdMII HC<br />
**[[1fmw]] – DdMII HC+ATP<br />
**[[1fmw]] – DdMII HC+ATP<br />
**[[1jwy]], [[1jx2]] – DdMII HC+dynamin-1<br />
**[[1jwy]], [[1jx2]] – DdMII HC+dynamin-1<br />
**[[1d0x]], [[1d0y]], [[1d0z]], [[1d1a]], [[1d1b]], [[1d1c]] – DdMII HC (mutant)+BeF3 derivative<br />
**[[1d0x]], [[1d0y]], [[1d0z]], [[1d1a]], [[1d1b]], [[1d1c]] – DdMII HC (mutant)+BeF3 derivative<br />
**[[1g8x]] – DdMII+actinin 3<br />
**[[1g8x]] – DdMII+actinin 3<br />
-
**[[2jj9]], [[2x9h]] - DdMII HC+ADP-VO4<br />
+
**[[2jj9]], [[2x9h]], [[7b19]], [[7b1a]] - DdMII HC+ADP-VO4<br />
**[[3mkd]] - DdMII HC MD (mutant) + ADP-VO4 <br />
**[[3mkd]] - DdMII HC MD (mutant) + ADP-VO4 <br />
**[[1lvk]], [[1mma]], [[1mmg]], [[1mmn]] – DdMII HC (mutant)+Mg+nucleotide<br />
**[[1lvk]], [[1mma]], [[1mmg]], [[1mmn]] – DdMII HC (mutant)+Mg+nucleotide<br />
Line 61: Line 66:
**[[2aka]] - DdMII HC+dynamin-1<br />
**[[2aka]] - DdMII HC+dynamin-1<br />
**[[2xel]], [[4ae3]] – DdMII HC + inhibitor<br />
**[[2xel]], [[4ae3]] – DdMII HC + inhibitor<br />
 +
**[[6z7u]] - DdMII HC + ADP + blebibistatin<br />
**[[6ixo]] – yMII GTD - yeast<br />
**[[6ixo]] – yMII GTD - yeast<br />
 +
**[[6eyw]] – yMII CBD <br />
**[[1n2d]] – yMII LC+IQ2 IQ3 motifs from Myo2p<br />
**[[1n2d]] – yMII LC+IQ2 IQ3 motifs from Myo2p<br />
**[[1m45]] - yMII LC+IQ2 motif from Myo2p<br />
**[[1m45]] - yMII LC+IQ2 motif from Myo2p<br />
Line 70: Line 77:
**[[5e4h]] - smMII HC kinase domain – slime mold<br />
**[[5e4h]] - smMII HC kinase domain – slime mold<br />
**[[5e9e]] - smMII HC kinase domain + AMPPNP <br />
**[[5e9e]] - smMII HC kinase domain + AMPPNP <br />
 +
**[[7kog]] - wbMII HC coiled-coil domain – water bug - Cryo EM<br />
* Myosin III
* Myosin III
 +
**[[6jle]] - hMIIIa tail domain + MORN4<br />
**[[2btt]] – ScMIII SH3 domain – NMR<br />
**[[2btt]] – ScMIII SH3 domain – NMR<br />
**[[1ruw]], [[1va7]] – yMIII SH3 domain
**[[1ruw]], [[1va7]] – yMIII SH3 domain
Line 78: Line 87:
*Myosin IV
*Myosin IV
 +
**[[6ysy]] - rMV HC+LC+Mg-ADP-VO4<br/>
 +
**[[7nep]] - mMV HC+LC + actin + tropomyocin – Cryo EM<br/>
 +
**[[7qio]] - mMV HC+LC – Cryo EM<br/>
 +
**[[7qin]] - mMV HC in actomyosin complex – Cryo EM<br/>
**[[3mmi]] – yMIV GTD <br />
**[[3mmi]] – yMIV GTD <br />
**[[4ll6]] - yMIV GTD (mutant)<br />
**[[4ll6]] - yMIV GTD (mutant)<br />
**[[4ll8]] - yMIV GTD (mutant) + SHE3P<br />
**[[4ll8]] - yMIV GTD (mutant) + SHE3P<br />
**[[6qdj]] – MIV – ''Caenorhabditis elegans'' <br />
**[[6qdj]] – MIV – ''Caenorhabditis elegans'' <br />
- 
-
*Myosin V
 
- 
-
**[[6eyw]] - yMV CBD<br />
 
* Myosin V (Unconventional myosin)
* Myosin V (Unconventional myosin)
-
**[[1w7i]] – cMV HC+LC+Mg+ADP<br />
 
-
**[[1w7j]] - cMV HC+LC+BEFX+ADP<br />
 
-
**[[1w8j]] – cMV HC<br />
 
-
**[[1oe9]] – cMV HC+LC<br />
 
-
**[[1br2]] – cMV HC+Mg+ADP+AlF4<br />
 
-
**[[2fcd]] – ScMV LC N-terminal – ''Saccharomices cerevisiae'' – NMR<br />
 
-
**[[2fce]] – ScMV LC C-terminal – NMR<br />
 
-
**[[2f6h]] – ScMV CBD<br />
 
-
**[[1yp5]], [[1zuy]] – yMV SH3 domain<br />
 
-
**[[4zlk]] - mMVA + calmodulin<br />
 
-
**[[2ix7]] – mMVA IQ motif +apo-calmodulin <br />
 
-
**[[3wb8]] – mMVA GTD<br />
 
-
**[[4j5l]], [[4j5m]] – hMVA GTD<br />
 
-
**[[4kp3]] – mMVA GTD + RILP-like protein + melanophilin<br />
 
-
**[[4lli]] – hMVA CBD<br />
 
**[[4lx1]] – hMVA GTD<br />
**[[4lx1]] – hMVA GTD<br />
**[[4lx2]] – hMVA GTD + melanphilin<br />
**[[4lx2]] – hMVA GTD + melanphilin<br />
**[[5jcz]] – hMVA GTD + RAB-11<br />
**[[5jcz]] – hMVA GTD + RAB-11<br />
**[[5jcy]] – hMVA GTD + SPIR-2<br />
**[[5jcy]] – hMVA GTD + SPIR-2<br />
 +
**[[7pm0]], [[7pm1]], [[7pm2]], [[7pm5]], [[7pm6]], [[7pm7]], [[7pm8]], [[7pm9]], [[7pma]], [[7pmb]], [[7pmc]], [[7pmd]], [[7pme]], [[7pmf]], [[7pmg]], [[7pmh]], [[7pmi]], [[7pmj]], [[7pml]] – hMVA + MII + actin + phalloidin – Cryo EM<br />
**[[4lnz]] – hMVB GTD<br />
**[[4lnz]] – hMVB GTD<br />
**[[4lwz]], [[4lx0]] – hMVB GTD + RAS-related protein<br />
**[[4lwz]], [[4lx0]] – hMVB GTD + RAS-related protein<br />
**[[5hmp]], [[4zg4]] – hMVC <br />
**[[5hmp]], [[4zg4]] – hMVC <br />
**[[4l8t]] – hMVC CBD<br />
**[[4l8t]] – hMVC CBD<br />
 +
**[[7yv9]] - mMVA + calmodulin – Cryo EM<br/>
 +
**[[4j5l]], [[4j5m]] – hMVA GTD<br />
 +
**[[4zlk]] - mMVA + calmodulin<br />
 +
**[[2ix7]] – mMVA IQ motif +apo-calmodulin <br />
 +
**[[3wb8]] – mMVA GTD<br />
 +
**[[4kp3]] – mMVA GTD + RILP-like protein + melanophilin<br />
 +
**[[6ku0]] – mMVA GTD + MICAL-1 peptide<br />
 +
**[[7plt]], [[7plu]], [[7plv]], [[7plw]], [[7plx]], [[7ply]], [[7plz]] - cMVA HC in actomyosin complex – Cryo EM<br/>
 +
**[[1w7i]] – cMV HC+LC+Mg+ADP<br />
 +
**[[1w7j]] - cMV HC+LC+BEFX+ADP<br />
 +
**[[1w8j]] – cMV HC<br />
 +
**[[1oe9]] – cMV HC+LC<br />
 +
**[[1br2]] – cMV HC+Mg+ADP+AlF4<br />
 +
**[[2fcd]] – yMV LC N-terminal – yeast – NMR<br />
 +
**[[2fce]] – yMV LC C-terminal – NMR<br />
 +
**[[2f6h]] – yMV CBD<br />
 +
**[[1yp5]], [[1zuy]] – yMV SH3 domain<br />
* Myosin VI
* Myosin VI
-
**[[2kia]] – mMVI CBD – mouse – NMR<br />
 
-
**[[2ld3]] – mMVI lever arm extension - NMR<br />
 
-
**[[3h8d]] - mMVI CBD+Dab2 peptide<br />
 
**[[4e7z]], [[4pk4]], [[4pjn]], [[4pjm]] - pMVI<br />
**[[4e7z]], [[4pk4]], [[4pjn]], [[4pjm]] - pMVI<br />
**[[4e7s]] - pMVI (mutant)<br />
**[[4e7s]] - pMVI (mutant)<br />
Line 130: Line 139:
**[[6bnw]], [[6bnq]], [[6bnp]] – pMVI + actin – Cryo EM<br />
**[[6bnw]], [[6bnq]], [[6bnp]] – pMVI + actin – Cryo EM<br />
**[[6bnv]] – pMVI + actin + calmodulin – Cryo EM<br />
**[[6bnv]] – pMVI + actin + calmodulin – Cryo EM<br />
-
**[[6bnv]] – MVI residus 1-69 – ''Meriones unguiculatus''<br />
+
**[[2kia]] – mMVI CBD – mouse – NMR<br />
 +
**[[2ld3]] – mMVI lever arm extension - NMR<br />
 +
**[[3h8d]] - mMVI CBD+Dab2 peptide<br />
 +
**[[6obi]] – MVI – ''Meriones unguiculatus''<br />
*Unconventional myosin VI
*Unconventional myosin VI
**[[6j56]] – hMVI CBD + TOM1 peptide <br />
**[[6j56]] – hMVI CBD + TOM1 peptide <br />
-
**[[5v6h]] – mMVI + GIPC2 <br />
 
-
**[[5v6e]] – mMVI + GIPC1 <br />
 
**[[4pfp]], [[4pfo]], [[5o2l]] – pMVI MD <br />
**[[4pfp]], [[4pfo]], [[5o2l]] – pMVI MD <br />
**[[4pjl]] – pMVI MD (mutant) <br />
**[[4pjl]] – pMVI MD (mutant) <br />
**[[4pjj]] – pMVI MD + calmodulin <br />
**[[4pjj]] – pMVI MD + calmodulin <br />
 +
**[[5v6h]] – mMVI + GIPC2 <br />
 +
**[[5v6e]] – mMVI + GIPC1 <br />
*Myosin VII
*Myosin VII
-
**[[2i0n]] - DdMVII SH3 domain - NMR<br />
 
-
**[[3pvl]] - mMVII SH3 domain+hUsher syndrome type 1G protein<br />
 
**[[4db1]] – hMVII HC<br />
**[[4db1]] – hMVII HC<br />
 +
**[[8enc]] - hMVII HC + actin + tropomyocin – Cryo EM<br/>
**[[5n6a]] – bMVII HC <br />
**[[5n6a]] – bMVII HC <br />
**[[5tby]] – bMVII HC + MIII LC + MLC-2V <br />
**[[5tby]] – bMVII HC + MIII LC + MLC-2V <br />
**[[6fsa]], [[5n69]] – bMVII HC + MIII LC <br />
**[[6fsa]], [[5n69]] – bMVII HC + MIII LC <br />
 +
**[[6x5z]] – bMVII + cActin + hTropomyosin – Cryo EM<br />
 +
**[[7jh7]] - pMVII HC + actin + tropomyocin – Cryo EM<br/>
 +
**[[3pvl]] - mMVII SH3 domain+hUsher syndrome type 1G protein<br />
 +
**[[2i0n]] - DdMVII SH3 domain - NMR<br />
*Unconventional myosin VII
*Unconventional myosin VII
-
**[[5wst]] – mMVIIA SAH <br />
 
**[[5mv7]] – hMVIIB C-terminal <br />
**[[5mv7]] – hMVIIB C-terminal <br />
**[[5xbf]], [[5mv8]] – hMVIIB C-terminal + harmonin <br />
**[[5xbf]], [[5mv8]] – hMVIIB C-terminal + harmonin <br />
Line 158: Line 172:
**[[5wsv]] – hMVIIA IQ5 + calmodulin <br />
**[[5wsv]] – hMVIIA IQ5 + calmodulin <br />
**[[5wsu]] – hMVIIA IQ5-SAH + calmodulin <br />
**[[5wsu]] – hMVIIA IQ5-SAH + calmodulin <br />
 +
**[[5wst]] – mMVIIA SAH <br />
**[[5f3y]] – mMVIIB + ANKS4B <br />
**[[5f3y]] – mMVIIB + ANKS4B <br />
**[[5ejr]] – DdMVIIB MF2 domain <br />
**[[5ejr]] – DdMVIIB MF2 domain <br />
Line 188: Line 203:
**[[6bih]] – cMXI HC + actin – Cryo EM<br />
**[[6bih]] – cMXI HC + actin – Cryo EM<br />
-
*Unconventional myosin XIV
+
*Unconventional myosin XI
 +
 
 +
**[[7kch]] – cMXI + actin + ADP – Cryo EM <br />
 +
**[[7dhw]] – AtMXI MD + ADP - ''Arabidopsis thaliana'' <br />
 +
 
 +
*Myosin XIV
 +
 
 +
**[[5jlh]] – hMIV/actinin + actin + tropomyocin + ADP – Cryo EM<br />
 +
 
 +
*Unconventional myosin XIV or myosin-A
 +
 
 +
**[[6due]] – TgMXIV – ''Toxoplasma gondii'' <br />
 +
**[[6tj5]], [[6tj6]], [[6tj7]] – TgMIV ELC + calmodulin<br />
 +
**[[6i7d]] – PfMI – ''Plasmodium falciparum''<br />
 +
**[[6tj4]] – PfMIV ELC N-terminal<br />
 +
**[[6tj3]] – PfMIV ELC N-termina - NMRl<br />
 +
**[[6i7e]], [[6ycx]], [[6ycy]], [[6ycz]] – PfMI + ADP<br />
 +
**[[6zn3]] – PfMIV ELC + myosin A tail end interacting protein<br />
 +
**[[6tu7]] – PfMIV + actin + ADP – Cryo EM<br />
 +
**[[7aln]] – PfMIV (mutant) + actin – Cryo EM<br />
 +
 
 +
*Unconventional myosin XV
 +
 
 +
**[[7r91]], [[7rb8]], [[7rb9]] – mMXV + actin + ADP – Cryo EM <br />
 +
**[[7udt]], [[7udu]] – cMXV motor domain + actin + regulatory LC + ADP – Cryo EM <br />
 +
 
 +
*Myosin XVII
-
**[[6due]] – MXIV – ''Toxoplasma gondii'' <br />
+
**[[7kfl]] – AtMXVII CBD <br />
*Flight muscle myosin
*Flight muscle myosin
Line 210: Line 251:
**[[1dfl]] - sRLC+sELC+sHC+ADP-VO4+Mg<br />
**[[1dfl]] - sRLC+sELC+sHC+ADP-VO4+Mg<br />
**[[1wdc]] - sRLC+sELC+sHC - digested<br />
**[[1wdc]] - sRLC+sELC+sHC - digested<br />
-
**[[3dtp]] - RLC+HC+ELC – tarantula – Cryo EM
+
**[[3dtp]] - RLC+HC+ELC – tarantula – Cryo EM<br />
 +
**[[6so3]] - wbRLC+HC+ELC – Cryo EM<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Myosin

Updated on 10-July-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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