6l5t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of SADS-CoV Papain Like protease== |
| - | + | <StructureSection load='6l5t' size='340' side='right'caption='[[6l5t]], [[Resolution|resolution]] 1.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6l5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Swine_acute_diarrhea_syndrome_coronavirus Swine acute diarrhea syndrome coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L5T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l5t OCA], [https://pdbe.org/6l5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l5t RCSB], [https://www.ebi.ac.uk/pdbsum/6l5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l5t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A385H8D7_9ALPC A0A385H8D7_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928] Nsp9 is a ssRNA-binding protein.[ARBA:ARBA00003140] The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.[ARBA:ARBA00003315] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562] The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.[ARBA:ARBA00003368] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Swine acute diarrhea syndrome coronavirus]] | ||
| + | [[Category: Fan CP]] | ||
Current revision
The crystal structure of SADS-CoV Papain Like protease
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