This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3fhc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:29, 1 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='3fhc' size='340' side='right'caption='[[3fhc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3fhc' size='340' side='right'caption='[[3fhc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3fhc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3fhc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHC FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fht|3fht]], [[2oit|2oit]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nup214 (Residues 1-405) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Dbp5 (Residues 68-302) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhc OCA], [https://pdbe.org/3fhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhc RCSB], [https://www.ebi.ac.uk/pdbsum/3fhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhc ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhc OCA], [http://pdbe.org/3fhc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhc RCSB], [http://www.ebi.ac.uk/pdbsum/3fhc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhc ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
+
[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
+
[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 34: Line 33:
==See Also==
==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Helicase 3D structures|Helicase 3D structures]]
-
*[[Nucleoporin|Nucleoporin]]
+
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Conti, E]]
+
[[Category: Conti E]]
-
[[Category: Moeller, H von]]
+
[[Category: Von Moeller H]]
-
[[Category: Atp-binding]]
+
-
[[Category: Beta propeller]]
+
-
[[Category: Can]]
+
-
[[Category: Ddx19]]
+
-
[[Category: Dead-box helicase]]
+
-
[[Category: Dead-box protein 19b]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Helicase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Membrane]]
+
-
[[Category: Mrna export]]
+
-
[[Category: Mrna transport]]
+
-
[[Category: Nuclear pore complex]]
+
-
[[Category: Nucleoporin]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Protein transport]]
+
-
[[Category: Proto-oncogene]]
+
-
[[Category: Reca-like]]
+
-
[[Category: Rna dependent atpase]]
+
-
[[Category: Rna-binding]]
+
-
[[Category: Translocation]]
+
-
[[Category: Transport]]
+
-
[[Category: Transport protein-hydrolase complex]]
+

Current revision

Crystal structure of human Dbp5 in complex with Nup214

PDB ID 3fhc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fhc"
Personal tools